TY - JOUR
T1 - Air pollutant exposure and stove use assessment methods for the household air pollution intervention network (HAPIN) trial
AU - Johnson, Michael A.
AU - Steenland, Kyle
AU - Piedrahita, Ricardo
AU - Clark, Maggie L.
AU - Pillarisetti, Ajay
AU - Balakrishnan, Kalpana
AU - Peel, Jennifer L.
AU - Naeher, Luke P.
AU - Liao, Jiawen
AU - Wilson, Daniel
AU - Sarnat, Jeremy
AU - Underhill, Lindsay J.
AU - Burrowes, Vanessa
AU - McCracken, John P.
AU - Rosa, Ghislaine
AU - Rosenthal, Joshua
AU - Sambandam, Sankar
AU - de Leon, Oscar
AU - Kirby, Miles A.
AU - Kearns, Katherine
AU - Checkley, William
AU - Clasen, Thomas
N1 - Funding Information:
The Household Air Pollution Intervention Network (HAPIN) trial is funded by the National Institutes of Health (NIH cooperative agreement 1UM1HL134590) in collaboration with the Bill & Melinda Gates Foundation [OPP1131279]. A.P. was partially supported by the HERCULES Center P30ES019776. We thank R. Chartier, C. Garland, A. Lovvorn, and S. Jabbarzadeh for their input and support in developing the exposure sampling materials and protocols. We are also thankful to the field teams at each of the research centers for their feedback and input. A multidisciplinary, independent Data and Safety Monitoring Board (DSMB) appointed by the National Heart, Lung, and Blood Institute (NHLBI) monitors the quality of the data and protects the safety of patients enrolled in the HAPIN trial. NHLBI DSMB: N.R. Cook, S. Hecht, C. Karr, K.H. Kavounis, D.-Y. Kim, J. Millum, L.A. Reineck, N. Sathiakumar, P.K. Whelton, and G.G. Weinmann. Program Coordination: G. Rodgers, Bill & Melinda Gates Foundation; C.L. Thompson, National Institute of Environmental Health Science; M.J. Parascandola, National Cancer Institute; D.M. Krotoski, Eunice Kennedy Shriver National Institute of Child Health and Human Development; J.P. Rosenthal, Fogarty International Center; C.R. Nierras, NIH Office of Strategic Coordination Common Fund; and A. Punturieri and B.S. Schmetter, NHLBI. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the NIH, Department of Health and Human Services, or the U.S. Government.
Publisher Copyright:
© 2020, Public Health Services, US Dept of Health and Human Services. All rights reserved.
PY - 2020/4
Y1 - 2020/4
N2 - BACKGROUND: High quality personal exposure data is fundamental to understanding the health implications of household energy interventions, interpreting analyses across assigned study arms, and characterizing exposure–response relationships for household air pollution. This paper describes the exposure data collection for the Household Air Pollution Intervention Network (HAPIN), a multicountry randomized controlled trial of liquefied petroleum gas stoves and fuel among 3,200 households in India, Rwanda, Guatemala, and Peru. OBJECTIVES: The primary objectives of the exposure assessment are to estimate the exposure contrast achieved following a clean fuel intervention and to provide data for analyses of exposure–response relationships across a range of personal exposures. METHODS: Exposure measurements are being conducted over the 3-y time frame of the field study. We are measuring fine particulate matter [PM < 2:5 lm in aerodynamic diameter (PM2:5)] with the Enhanced Children’s MicroPEM™ (RTI International), carbon monoxide (CO) with the USB-EL-CO (Lascar Electronics), and black carbon with the OT21 transmissometer (Magee Scientific) in pregnant women, adult women, and children <1 year of age, primarily via multiple 24-h personal assessments (three, six, and three measurements, respectively) over the course of the 18month follow-up period using lightweight monitors. For children we are using an indirect measurement approach, combining data from area monitors and locator devices worn by the child. For a subsample (up to 10%) of the study population, we are doubling the frequency of measurements in order to estimate the accuracy of subject-specific typical exposure estimates. In addition, we are conducting ambient air monitoring to help characterize potential contributions of PM2:5 exposure from background concentration. Stove use monitors (Geocene) are being used to assess compliance with the intervention, given that stove stacking (use of traditional stoves in addition to the intervention gas stove) may occur. CONCLUSIONS: The tools and approaches being used for HAPIN to estimate personal exposures build on previous efforts and take advantage of new technologies. In addition to providing key personal exposure data for this study, we hope the application and learnings from our exposure assessment will help inform future efforts to characterize exposure to household air pollution and for other contexts. https://doi.org/10.1289/EHP6422.
AB - BACKGROUND: High quality personal exposure data is fundamental to understanding the health implications of household energy interventions, interpreting analyses across assigned study arms, and characterizing exposure–response relationships for household air pollution. This paper describes the exposure data collection for the Household Air Pollution Intervention Network (HAPIN), a multicountry randomized controlled trial of liquefied petroleum gas stoves and fuel among 3,200 households in India, Rwanda, Guatemala, and Peru. OBJECTIVES: The primary objectives of the exposure assessment are to estimate the exposure contrast achieved following a clean fuel intervention and to provide data for analyses of exposure–response relationships across a range of personal exposures. METHODS: Exposure measurements are being conducted over the 3-y time frame of the field study. We are measuring fine particulate matter [PM < 2:5 lm in aerodynamic diameter (PM2:5)] with the Enhanced Children’s MicroPEM™ (RTI International), carbon monoxide (CO) with the USB-EL-CO (Lascar Electronics), and black carbon with the OT21 transmissometer (Magee Scientific) in pregnant women, adult women, and children <1 year of age, primarily via multiple 24-h personal assessments (three, six, and three measurements, respectively) over the course of the 18month follow-up period using lightweight monitors. For children we are using an indirect measurement approach, combining data from area monitors and locator devices worn by the child. For a subsample (up to 10%) of the study population, we are doubling the frequency of measurements in order to estimate the accuracy of subject-specific typical exposure estimates. In addition, we are conducting ambient air monitoring to help characterize potential contributions of PM2:5 exposure from background concentration. Stove use monitors (Geocene) are being used to assess compliance with the intervention, given that stove stacking (use of traditional stoves in addition to the intervention gas stove) may occur. CONCLUSIONS: The tools and approaches being used for HAPIN to estimate personal exposures build on previous efforts and take advantage of new technologies. In addition to providing key personal exposure data for this study, we hope the application and learnings from our exposure assessment will help inform future efforts to characterize exposure to household air pollution and for other contexts. https://doi.org/10.1289/EHP6422.
UR - http://www.scopus.com/inward/record.url?scp=85084169824&partnerID=8YFLogxK
U2 - 10.1289/EHP65422
DO - 10.1289/EHP65422
M3 - Article
C2 - 32347764
AN - SCOPUS:85084169824
SN - 0091-6765
VL - 128
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
IS - 4
M1 - 047009
ER -