The intestinal immune system is challenged daily with the task of recognizing and eliminating pathogens while simultaneously tolerating dietary and commensal antigens. All components must effectively coordinate to differentiate a continual barrage of environmental cues and mount appropriate responses dependent on the nature of the stimuli encountered. Playing a pivotal role, the aryl hydrocarbon receptor (AHR) is a chemical sensor that detects both dietary and microbial cues and is important for development, maintenance, and function of several types of intestinal immune cells, particularly innate lymphoid cells (ILCs) and T cells. In this review, we will highlight recent advances in our knowledge of the role of AHR signaling in ILCs, T cells, B cells, and dendritic cells.

Original languageEnglish
Pages (from-to)371-377
Number of pages7
JournalSeminars in Immunopathology
Issue number4
StatePublished - Jul 1 2018


  • AHR
  • Aryl hydrocarbon receptor
  • DP IEL
  • ILCs
  • Innate lymphoid cells


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