Aging signaling pathways and circadian clock-dependent metabolic derangements

Maria Florencia Tevy, Jadwiga Giebultowicz, Zachary Pincus, Gianluigi Mazzoccoli, Manlio Vinciguerra

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.

Original languageEnglish
Pages (from-to)229-237
Number of pages9
JournalTrends in Endocrinology and Metabolism
Issue number5
StatePublished - May 2013


  • Aging
  • Circadian clock
  • Flies
  • Glucose metabolism
  • Insulin
  • Mice
  • Nutrients


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