TY - JOUR
T1 - Aging signaling pathways and circadian clock-dependent metabolic derangements
AU - Tevy, Maria Florencia
AU - Giebultowicz, Jadwiga
AU - Pincus, Zachary
AU - Mazzoccoli, Gianluigi
AU - Vinciguerra, Manlio
N1 - Funding Information:
We apologize to all those researchers who are not cited due to space limits. We thank Antonio Musarò for comments on the paper. M.V. is supported by the Foundation for Liver Research and by the Italian Ministry of Health. J.M.G. supported by National Institutes of Health (NIH) grants 1R21AG038989 and R21-NS-075500. Z.P. is supported by NIH grant 1K99AG04248701. G.M. is supported by grant RC1203ME46 from the Italian Ministry of Health.
PY - 2013/5
Y1 - 2013/5
N2 - The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.
AB - The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.
KW - Aging
KW - Circadian clock
KW - Flies
KW - Glucose metabolism
KW - Insulin
KW - Mice
KW - Nutrients
UR - http://www.scopus.com/inward/record.url?scp=84876989832&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2012.12.002
DO - 10.1016/j.tem.2012.12.002
M3 - Review article
C2 - 23299029
AN - SCOPUS:84876989832
SN - 1043-2760
VL - 24
SP - 229
EP - 237
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 5
ER -