TY - JOUR
T1 - Aggregation of lariat ethers attached to a membrane anchoring unit
AU - Djedovič, Natasha K.
AU - Ferdani, Riccardo
AU - Schlesinger, Paul H.
AU - Gokel, George W.
N1 - Funding Information:
We gratefully acknowledge support of this work by the NIH (GM-36262 to G. W. G.) and by the Kilo Foundation (to P. H. S.).
PY - 2002/12/16
Y1 - 2002/12/16
N2 - The GGGPGGG heptapeptide, when anchored by octadecylamine-diglycolic acid unit forms chloride-selective channels in bilayer. Crown ethers, differently anchored, have been used to form synthetic cation channels. Dialkylamine-diglycolic acid anchored crown ethers failed to form cation-selective channels. This might be due to an inability to insert in the bilayer. Their ability to form stable aggregates, reflective of the latter, was therefore studied.
AB - The GGGPGGG heptapeptide, when anchored by octadecylamine-diglycolic acid unit forms chloride-selective channels in bilayer. Crown ethers, differently anchored, have been used to form synthetic cation channels. Dialkylamine-diglycolic acid anchored crown ethers failed to form cation-selective channels. This might be due to an inability to insert in the bilayer. Their ability to form stable aggregates, reflective of the latter, was therefore studied.
KW - Amphiphiles
KW - Bilayers
KW - Crown ethers
UR - http://www.scopus.com/inward/record.url?scp=0037121858&partnerID=8YFLogxK
U2 - 10.1016/S0040-4020(02)01301-7
DO - 10.1016/S0040-4020(02)01301-7
M3 - Article
AN - SCOPUS:0037121858
SN - 0040-4020
VL - 58
SP - 10263
EP - 10268
JO - Tetrahedron
JF - Tetrahedron
IS - 51
ER -