Aggregation of lariat ethers attached to a membrane anchoring unit

Natasha K. Djedovič, Riccardo Ferdani, Paul H. Schlesinger, George W. Gokel

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The GGGPGGG heptapeptide, when anchored by octadecylamine-diglycolic acid unit forms chloride-selective channels in bilayer. Crown ethers, differently anchored, have been used to form synthetic cation channels. Dialkylamine-diglycolic acid anchored crown ethers failed to form cation-selective channels. This might be due to an inability to insert in the bilayer. Their ability to form stable aggregates, reflective of the latter, was therefore studied.

Original languageEnglish
Pages (from-to)10263-10268
Number of pages6
JournalTetrahedron
Volume58
Issue number51
DOIs
StatePublished - Dec 16 2002

Keywords

  • Amphiphiles
  • Bilayers
  • Crown ethers

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