Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells

Keyphrases

• Signaling Pathway 100%
• Non-canonical 100%
• Alpha-synuclein (α-syn) 100%
• NF-B 100%
• Monocytic Cells 100%
• Parkinson's Disease 80%
• Monocytes 60%
• Toll-like 40%
• Peripheral Inflammation 40%
• Liver 20%
• Neuroinflammation 20%
• Gene Expression 20%
• Macrophages 20%
• Genome-wide Association Study 20%
• Receptor Signaling 20%
• Specific Mechanisms 20%
• Neurodegenerative Diseases 20%
• CD40 20%
• Lewy Bodies 20%
• Disease Genome 20%
• Transcriptional Response 20%
• Disease Association 20%
• Osteoclast 20%
• Substantia Nigra 20%
• Dopaminergic Neurons 20%
• Pathway Activation 20%
• Transcriptional Program 20%
• Gene Pathway 20%
• Causal Role 20%
• Phenotype Analysis 20%
• Inflammatory Genes 20%
• Signaling Genes 20%
• TNF Gene 20%
• Chronic Neuroinflammation 20%
• THP-1 Cells 20%
• Gene Upregulation 20%
• Peripheral Site 20%
• NFKB2 20%
• Signaling Pathway Activation 20%
• α-Synuclein Fibrils 20%
• IL1B Gene 20%

Biochemistry, Genetics and Molecular Biology

• Toll-Like Receptor 100%
• Alpha-Synuclein 100%
• Upregulation 50%
• Gene Expression 50%
• Tumor Necrosis Factor 50%
• Genome-Wide Association Study 50%
• Myeloid 50%
• Macrophage 50%
• Osteoclast 50%
• Dopaminergic 50%
• RANK 50%
• IL1B 50%
• NFKB2 50%