TY - JOUR
T1 - Agenesis of the corpus callosum
T2 - Genetic, developmental and functional aspects of connectivity
AU - Paul, Lynn K.
AU - Brown, Warren S.
AU - Adolphs, Ralph
AU - Tyszka, J. Michael
AU - Richards, Linda J.
AU - Mukherjee, Pratik
AU - Sherr, Elliott H.
N1 - Funding Information:
We would like to thank the Sherr, Brown and Adolphs labs for helpful suggestions. We would also like to thank the Pfeiffer Foundation for supporting the 2006 AgCC interdisciplinary research symposium.
PY - 2007/4
Y1 - 2007/4
N2 - Agenesis of the corpus callosum (AgCC), a failure to develop the large bundle of fibres that connect the cerebral hemispheres, occurs in 1:4000 individuals. Genetics, animal models and detailed structural neuroimaging are now providing insights into the developmental and molecular bases of AgCC. Studies using neuropsychological, electroencephalogram and functional MRI approaches are examining the resulting impairments in emotional and social functioning, and have begun to explore the functional neuroanatomy underlying impaired higher-order cognition. The study of AgCC could provide insight into the integrated cerebral functioning of healthy brains, and may offer a model for understanding certain psychiatric illnesses, such as schizophrenia and autism.
AB - Agenesis of the corpus callosum (AgCC), a failure to develop the large bundle of fibres that connect the cerebral hemispheres, occurs in 1:4000 individuals. Genetics, animal models and detailed structural neuroimaging are now providing insights into the developmental and molecular bases of AgCC. Studies using neuropsychological, electroencephalogram and functional MRI approaches are examining the resulting impairments in emotional and social functioning, and have begun to explore the functional neuroanatomy underlying impaired higher-order cognition. The study of AgCC could provide insight into the integrated cerebral functioning of healthy brains, and may offer a model for understanding certain psychiatric illnesses, such as schizophrenia and autism.
UR - http://www.scopus.com/inward/record.url?scp=33947417339&partnerID=8YFLogxK
U2 - 10.1038/nrn2107
DO - 10.1038/nrn2107
M3 - Review article
C2 - 17375041
AN - SCOPUS:33947417339
SN - 1471-003X
VL - 8
SP - 287
EP - 299
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 4
ER -