Age-related changes in immune function of rats and the effect of long-term hypophysectomy

Mitchell Scott, Robert Bolla, W. Donner Denckla

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effect of age on the ability of rats to raise antibodies to sheep erythrocytes and on the number of IgM plaque-forming cells in the spleen was investigated. An age-related decline in both parameters was observed. Additionally, the possibility that long-term hypophysectomy coupled with minimal hormone replacement therapy might result in a delay and/or reversal of the age-related decline in immune function was studied. It was observed that long-term hypophysectomized rats responded better to immunization with sheep erythrocytes than did their age-matched unoperated littermates. The possible relationship of this to aging is discussed.

Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalMechanisms of Ageing and Development
Volume11
Issue number2
DOIs
StatePublished - Sep 1979
Externally publishedYes

Fingerprint Dive into the research topics of 'Age-related changes in immune function of rats and the effect of long-term hypophysectomy'. Together they form a unique fingerprint.

  • Cite this