Age-related changes in immune function of rats and the effect of long-term hypophysectomy

Mitchell Scott; Robert Bolla; W. Donner Denckla

doi:10.1016/0047-6374(79)90030-7

Age-related changes in immune function of rats and the effect of long-term hypophysectomy

Mitchell Scott, Robert Bolla, W. Donner Denckla

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The effect of age on the ability of rats to raise antibodies to sheep erythrocytes and on the number of IgM plaque-forming cells in the spleen was investigated. An age-related decline in both parameters was observed. Additionally, the possibility that long-term hypophysectomy coupled with minimal hormone replacement therapy might result in a delay and/or reversal of the age-related decline in immune function was studied. It was observed that long-term hypophysectomized rats responded better to immunization with sheep erythrocytes than did their age-matched unoperated littermates. The possible relationship of this to aging is discussed.

Original language	English
Pages (from-to)	127-136
Number of pages	10
Journal	Mechanisms of Ageing and Development
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/0047-6374(79)90030-7
State	Published - Sep 1979

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title = "Age-related changes in immune function of rats and the effect of long-term hypophysectomy",

abstract = "The effect of age on the ability of rats to raise antibodies to sheep erythrocytes and on the number of IgM plaque-forming cells in the spleen was investigated. An age-related decline in both parameters was observed. Additionally, the possibility that long-term hypophysectomy coupled with minimal hormone replacement therapy might result in a delay and/or reversal of the age-related decline in immune function was studied. It was observed that long-term hypophysectomized rats responded better to immunization with sheep erythrocytes than did their age-matched unoperated littermates. The possible relationship of this to aging is discussed.",

author = "Mitchell Scott and Robert Bolla and {Donner Denckla}, W.",

note = "Funding Information: This research was supported in part by grants from the Glenn Foundation for Medical Research and from the University of Missouri Faculty Research Council.",

year = "1979",

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AU - Scott, Mitchell

AU - Bolla, Robert

AU - Donner Denckla, W.

N1 - Funding Information: This research was supported in part by grants from the Glenn Foundation for Medical Research and from the University of Missouri Faculty Research Council.

PY - 1979/9

Y1 - 1979/9

N2 - The effect of age on the ability of rats to raise antibodies to sheep erythrocytes and on the number of IgM plaque-forming cells in the spleen was investigated. An age-related decline in both parameters was observed. Additionally, the possibility that long-term hypophysectomy coupled with minimal hormone replacement therapy might result in a delay and/or reversal of the age-related decline in immune function was studied. It was observed that long-term hypophysectomized rats responded better to immunization with sheep erythrocytes than did their age-matched unoperated littermates. The possible relationship of this to aging is discussed.

AB - The effect of age on the ability of rats to raise antibodies to sheep erythrocytes and on the number of IgM plaque-forming cells in the spleen was investigated. An age-related decline in both parameters was observed. Additionally, the possibility that long-term hypophysectomy coupled with minimal hormone replacement therapy might result in a delay and/or reversal of the age-related decline in immune function was studied. It was observed that long-term hypophysectomized rats responded better to immunization with sheep erythrocytes than did their age-matched unoperated littermates. The possible relationship of this to aging is discussed.

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U2 - 10.1016/0047-6374(79)90030-7

DO - 10.1016/0047-6374(79)90030-7

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AN - SCOPUS:0018607580

SN - 0047-6374

VL - 11

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JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

IS - 2

ER -

Age-related changes in immune function of rats and the effect of long-term hypophysectomy

Abstract

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