Abstract
The effect of age on the ability of rats to raise antibodies to sheep erythrocytes and on the number of IgM plaque-forming cells in the spleen was investigated. An age-related decline in both parameters was observed. Additionally, the possibility that long-term hypophysectomy coupled with minimal hormone replacement therapy might result in a delay and/or reversal of the age-related decline in immune function was studied. It was observed that long-term hypophysectomized rats responded better to immunization with sheep erythrocytes than did their age-matched unoperated littermates. The possible relationship of this to aging is discussed.
Original language | English |
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Pages (from-to) | 127-136 |
Number of pages | 10 |
Journal | Mechanisms of Ageing and Development |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - Sep 1979 |