Abstract
The effect of age on the ability of rats to raise antibodies to sheep erythrocytes and on the number of IgM plaque-forming cells in the spleen was investigated. An age-related decline in both parameters was observed. Additionally, the possibility that long-term hypophysectomy coupled with minimal hormone replacement therapy might result in a delay and/or reversal of the age-related decline in immune function was studied. It was observed that long-term hypophysectomized rats responded better to immunization with sheep erythrocytes than did their age-matched unoperated littermates. The possible relationship of this to aging is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 127-136 |
| Number of pages | 10 |
| Journal | Mechanisms of Ageing and Development |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 1979 |
| Externally published | Yes |
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Scott, M., Bolla, R., & Donner Denckla, W. (1979). Age-related changes in immune function of rats and the effect of long-term hypophysectomy. Mechanisms of Ageing and Development, 11(2), 127-136. https://doi.org/10.1016/0047-6374(79)90030-7