@article{489fe71423a344338e2b627bf1aa91cc,
title = "Age-period-cohort analysis of secular trends in onset of major depression: Findings in siblings of patients with major affective disorder",
abstract = "Analyses of data from the NIMH-CRB Collaborative Depression Study on age at onset of Major Depressive Disorder (MDD) in 1144 directly interviewed siblings of patients with major affective disorder show a strong secular trend toward increased lifetime risk and earlier onset in successive cohorts of birth since 1930. The proportionate increases in the instantaneous probabilities (hazard) of onset of MDD for each one year difference in year of birth were 5% for brothers and 7% for sisters. Age-period-cohort analysis suggests a powerful period effect may be responsible for this secular trend in rates of MDD, with rates of onset for siblings between 15 and 50 years of age doubling between the 1960s and 1970s. Possible artifacts are investigated.",
author = "Lavori, {Philip W.} and Klerman, {Gerald L.} and Keller, {Martin B.} and Theodore Reich and John Rice and Jean Endicott",
note = "Funding Information: *Requests for reprints should be addressed to: P. Lavori, Ph.D., Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, U.S.A. (617) 726-8467. tFrom the National Institute of Mental Health-Clinical Research Branch Collaborative Program on the Psychobiology of Depression-Clinical Studies, conducted with the participation of the following investigators: G. L. Klerman, M.D. (Chairperson), (Boston); R.M.A. Hirshfeld, M.D. (Project Director and Co-Chairperson) and P. Griffith, Ph.D. (Washington D.C.); M. B. Keller, M.D. and P. Lavori, Ph.D. (Boston); J. A. Fawcett, M.D. and W. A. Scheftner, M.D. (Chicago); N. C. Andreasen, M.D., W. Coryell, M.D., G. Winokur, M.D., and P. Wasek, B.A. (Iowa City); J. Endicott, Ph.D., P. McDonald-Scott, M.A. and J. E. Loth, M.S.W. (New York); J. Rice, Ph.D., T. Reich, M.D., and D. Altis, B.A. (St. Louis). Other contributors include: P. J. Clayton, M.D., M. M. Katz, Ph.D., E. Robins, M.D., R. W. Shapiro, M.D. and R. Spitzer, M.D. This paper was reviewed and endorsed by the Publications Committee of the Collaborative Depression Study. This work was supported by Grants 2UOl MH25478-09SRC and MH-37685 from the National Institute of Mental Health.",
year = "1987",
doi = "10.1016/0022-3956(87)90006-9",
language = "English",
volume = "21",
pages = "23--35",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
number = "1",
}