TY - JOUR
T1 - Age at time of infarction differentially affects the remodeling responses in viable cardiac tissue in young versus old rats
AU - Handley, S. M.
AU - Ngo, F.
AU - Hall, C.
AU - Allen, J.
AU - McLean, M.
AU - Lanza, G.
AU - Miller, J. G.
AU - Wickline, S.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - To determine whether age influences ventricular remodeling responses in viable cardiac tissue, an attempt was made to characterize remodeling after myocardial infarction in Fischer 344 rats that undergo natural age-related changes in heart structure and function that parallel those observed in human hearts. Data suggest that alterations in microscopic structure and material properties associated with remodeling of viable myocardial tissue differ depending on subject age, as delineated by quantitative acoustic microscopy. Furthermore, the remodeling process appear to have a greater influence in the viable non-infarcted zones than in the infarct zones thus imposing deleterious restrictions on overall ventricular performance.
AB - To determine whether age influences ventricular remodeling responses in viable cardiac tissue, an attempt was made to characterize remodeling after myocardial infarction in Fischer 344 rats that undergo natural age-related changes in heart structure and function that parallel those observed in human hearts. Data suggest that alterations in microscopic structure and material properties associated with remodeling of viable myocardial tissue differ depending on subject age, as delineated by quantitative acoustic microscopy. Furthermore, the remodeling process appear to have a greater influence in the viable non-infarcted zones than in the infarct zones thus imposing deleterious restrictions on overall ventricular performance.
UR - http://www.scopus.com/inward/record.url?scp=0035729009&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2001.991929
DO - 10.1109/ULTSYM.2001.991929
M3 - Article
AN - SCOPUS:0035729009
SN - 1051-0117
VL - 2
SP - 1181
EP - 1184
JO - Proceedings of the IEEE Ultrasonics Symposium
JF - Proceedings of the IEEE Ultrasonics Symposium
ER -