Age at time of infarction differentially affects the remodeling responses in viable cardiac tissue in young versus old rats

S. M. Handley, F. Ngo, C. Hall, J. Allen, M. McLean, G. Lanza, J. G. Miller, S. Wickline

Research output: Contribution to journalArticlepeer-review

Abstract

To determine whether age influences ventricular remodeling responses in viable cardiac tissue, an attempt was made to characterize remodeling after myocardial infarction in Fischer 344 rats that undergo natural age-related changes in heart structure and function that parallel those observed in human hearts. Data suggest that alterations in microscopic structure and material properties associated with remodeling of viable myocardial tissue differ depending on subject age, as delineated by quantitative acoustic microscopy. Furthermore, the remodeling process appear to have a greater influence in the viable non-infarcted zones than in the infarct zones thus imposing deleterious restrictions on overall ventricular performance.

Original languageEnglish
Pages (from-to)1181-1184
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Volume2
DOIs
StatePublished - 2001

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