Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Chun Pin Chang; Shen Chih Chang; Shu Chun Chuang; Julien Berthiller; Gilles Ferro; Keitaro Matsuo; Victor Wünsch-Filho; Tatiana N. Toporcov; Marcos Brasilino de Carvalho; Carlo La Vecchia; Andrew F. Olshan; Jose P. Zevallos; Diego Serraino; Joshua Muscat; Erich M. Sturgis; Guojun Li; Hal Morgenstern; Fabio Levi; Luigino Dal Maso; Elaine Smith; Karl Kelsey; Michael McClean; Thomas L. Vaughan; Philip Lazarus; Heribert Ramroth; Chu Chen; Stephen M. Schwartz; Deborah M. Winn; Cristina Bosetti; Valeria Edefonti; Werner Garavello; Eva Negri; Richard B. Hayes; Mark P. Purdue; Stefania Boccia; Gabriella Cadoni; Oxana Shangina; Rosalina Koifman; Maria Paula Curado; Marta Vilensky; Beata Swiatkowska; Rolando Herrero; Silvia Franceschi; Simone Benhamou; Leticia Fernandez; Ana M.B. Menezes; Alexander W. Daudt; Dana Mates; Stimson Schantz; Guo Pei Yu; Jolanta Lissowska; Hermann Brenner; Eleonora Fabianova; Peter Rudnai; Paul Brennan; Paolo Boffetta; Zuo Feng Zhang; Mia Hashibe; Yuan Chin Amy Lee

doi:10.1016/j.canep.2019.101615

Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Chun Pin Chang, Shen Chih Chang, Shu Chun Chuang, Julien Berthiller, Gilles Ferro, Keitaro Matsuo, Victor Wünsch-Filho, Tatiana N. Toporcov, Marcos Brasilino de Carvalho, Carlo La Vecchia, Andrew F. Olshan, Jose P. Zevallos, Diego Serraino, Joshua Muscat, Erich M. Sturgis, Guojun Li, Hal Morgenstern, Fabio Levi, Luigino Dal Maso, Elaine SmithKarl Kelsey, Michael McClean, Thomas L. Vaughan, Philip Lazarus, Heribert Ramroth, Chu Chen, Stephen M. Schwartz, Deborah M. Winn, Cristina Bosetti, Valeria Edefonti, Werner Garavello, Eva Negri, Richard B. Hayes, Mark P. Purdue, Stefania Boccia, Gabriella Cadoni, Oxana Shangina, Rosalina Koifman, Maria Paula Curado, Marta Vilensky, Beata Swiatkowska, Rolando Herrero, Silvia Franceschi, Simone Benhamou, Leticia Fernandez, Ana M.B. Menezes, Alexander W. Daudt, Dana Mates, Stimson Schantz, Guo Pei Yu, Jolanta Lissowska, Hermann Brenner, Eleonora Fabianova, Peter Rudnai, Paul Brennan, Paolo Boffetta, Zuo Feng Zhang, Mia Hashibe, Yuan Chin Amy Lee

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Abstract

Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR_{<10 years vs. ≥30 years}: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR_{<10 years vs. ≥30 years}: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.

Original language	English
Article number	101615
Journal	Cancer Epidemiology
Volume	63
DOIs	https://doi.org/10.1016/j.canep.2019.101615
State	Published - Dec 2019

Keywords

Age at start of tobacco use
Head and neck cancer
Hypopharyngeal cancer
Laryngeal cancer
Oral cancer
Oropharyngeal cancer

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10.1016/j.canep.2019.101615

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Chang, C. P., Chang, S. C., Chuang, S. C., Berthiller, J., Ferro, G., Matsuo, K., Wünsch-Filho, V., Toporcov, T. N., de Carvalho, M. B., La Vecchia, C., Olshan, A. F., Zevallos, J. P., Serraino, D., Muscat, J., Sturgis, E. M., Li, G., Morgenstern, H., Levi, F., Dal Maso, L., ... Lee, Y. C. A. (2019). Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE). Cancer Epidemiology, 63, [101615]. https://doi.org/10.1016/j.canep.2019.101615

@article{363ee4ab92e6466989e5e781d3fccf4f,

title = "Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)",

abstract = "Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR<10 years vs. ≥30 years: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR<10 years vs. ≥30 years: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.",

keywords = "Age at start of tobacco use, Head and neck cancer, Hypopharyngeal cancer, Laryngeal cancer, Oral cancer, Oropharyngeal cancer",

author = "Chang, {Chun Pin} and Chang, {Shen Chih} and Chuang, {Shu Chun} and Julien Berthiller and Gilles Ferro and Keitaro Matsuo and Victor W{\"u}nsch-Filho and Toporcov, {Tatiana N.} and {de Carvalho}, {Marcos Brasilino} and {La Vecchia}, Carlo and Olshan, {Andrew F.} and Zevallos, {Jose P.} and Diego Serraino and Joshua Muscat and Sturgis, {Erich M.} and Guojun Li and Hal Morgenstern and Fabio Levi and {Dal Maso}, Luigino and Elaine Smith and Karl Kelsey and Michael McClean and Vaughan, {Thomas L.} and Philip Lazarus and Heribert Ramroth and Chu Chen and Schwartz, {Stephen M.} and Winn, {Deborah M.} and Cristina Bosetti and Valeria Edefonti and Werner Garavello and Eva Negri and Hayes, {Richard B.} and Purdue, {Mark P.} and Stefania Boccia and Gabriella Cadoni and Oxana Shangina and Rosalina Koifman and Curado, {Maria Paula} and Marta Vilensky and Beata Swiatkowska and Rolando Herrero and Silvia Franceschi and Simone Benhamou and Leticia Fernandez and Menezes, {Ana M.B.} and Daudt, {Alexander W.} and Dana Mates and Stimson Schantz and Yu, {Guo Pei} and Jolanta Lissowska and Hermann Brenner and Eleonora Fabianova and Peter Rudnai and Paul Brennan and Paolo Boffetta and Zhang, {Zuo Feng} and Mia Hashibe and Lee, {Yuan Chin Amy}",

note = "Funding Information: This pooled analysis was supported by grants National Cancer Institute (NCI) R03CA113157 , National Institute of Dental and Craniofacial Research (NIDCR) R03DE016611 from the National Institutes of Health (NIH). Shen-Chih Chang was supported by a Special Training Award from the International Agency for Research on Cancer . The Aviano and Italy Multicenter studies were supported by Italian Association for Research on Cancer (AIRC) , Italian League Against Cancer , and Italian Ministry of Research . The Boston study was supported by grants R01CA078609 and R01CA100679 from the National Institutes of Health . The Central Europe study was supported by grant IC15- CT98-0332 from World Cancer Research Fund and the European Commission INCO-COPERNICUS Program . The France (1987–1992) study was supported by grant KFS1069-09-2000 from Swiss League against Cancer , grant FOR381.88 from Fribourg League against Cancer , grant AKT 617 from Swiss Cancer Research and grant 88D28 from Gustave-Roussy Institute . The Germany-Heidelberg study was supported by grant 01GB9702/3 from German Ministry of Education and Research . The Germany-Saarland study was supported by Ministry of Science, Research and Arts Baden-Wurttemberg . The Houston study was supported by grants R01ES11740 and R01CA100264 from the National Institutes of Health. The International Multicenter study was supported by grants FIS 97/0024 and FIS 97/0662 from Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government , BAE 01/5013 from International Union Against Cancer (UICC) , and Yamagiwa-Yoshida Memorial International Cancer Study Grant . The Iowa study was supported by grants NIDCR R01DE011979 , NIDCR R01DE013110 and FIRCA TW001500 from National Institutes of Health and was supported by Veterans Affairs Merit Review Funds . The Japan (2001–2005) study was supported by grant 17015052 from Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan , and grant H20-002 from the Ministry of Health, Labor and Welfare of Japan . The Latin America study was supported from grant 01/01768-2 from Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina , IMIM (Barcelona) , Fundaco de Amparo a` Pesquisa no Estado de Sao Paulo (FAPESP) , and grant IC18-CT97-0222 from European Commission . The Los Angeles study was supported by grants P50CA090388 , R01DA011386 , R03CA077954 , T32CA009142 , U01CA096134 and R21ES011667 from the National Institutes of Health, and was supported by the Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center . The Milan study was supported by the Italian Association for Cancer Research . The MSKCC was supported by grant R01CA051845 from the National Institutes of Health. The New York Multicenter study was supported by grants P01CA068384 and K07CA104231 from the National Institutes of Health. The North Carolina (1994–1997) and North Carolina (2002–2006) studies were supported by grant R01CA061188 from the National Institutes of Health, and grant P30ES010126 from the National Institute of Environmental Health Sciences . The Puerto Rico study was jointly funded by National Cancer Institute (NCI) and National Institute of Dental and Craniofacial Research (NIDCR) intramural programs, National Institutes of Health. The Rome study was supported by the Italian Association for Cancer Research (AIRC). The Sao Paolo study was supported by grant 10/51168-0 from the State of S{\~a}o Paulo Research Foundation (FAPESP). The Seattle (1985–1995) study was supported by R01CA048896 and R01DE012609 from the National Institutes of Health. The Seattle-LEO study was supported by R01CA030022 from the National Institutes of Health. The Switzerland study was supported by grants KFS-700 and OCS-1633 from Swiss League against Cancer and the Swiss Research against Cancer/Oncosuisse . The Tampa study was supported by grants P01CA068384 , K07CA104231 and R01DE013158 from the National Institutes of Health. The US Multicenter study was supported by the Intramural Program of the National Cancer Institute (NCI), National Institutes of Health. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = dec,

doi = "10.1016/j.canep.2019.101615",

language = "English",

volume = "63",

journal = "Cancer Epidemiology",

issn = "1877-7821",

}

Chang, CP, Chang, SC, Chuang, SC, Berthiller, J, Ferro, G, Matsuo, K, Wünsch-Filho, V, Toporcov, TN, de Carvalho, MB, La Vecchia, C, Olshan, AF, Zevallos, JP, Serraino, D, Muscat, J, Sturgis, EM, Li, G, Morgenstern, H, Levi, F, Dal Maso, L, Smith, E, Kelsey, K, McClean, M, Vaughan, TL, Lazarus, P, Ramroth, H, Chen, C, Schwartz, SM, Winn, DM, Bosetti, C, Edefonti, V, Garavello, W, Negri, E, Hayes, RB, Purdue, MP, Boccia, S, Cadoni, G, Shangina, O, Koifman, R, Curado, MP, Vilensky, M, Swiatkowska, B, Herrero, R, Franceschi, S, Benhamou, S, Fernandez, L, Menezes, AMB, Daudt, AW, Mates, D, Schantz, S, Yu, GP, Lissowska, J, Brenner, H, Fabianova, E, Rudnai, P, Brennan, P, Boffetta, P, Zhang, ZF, Hashibe, M & Lee, YCA 2019, 'Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)', Cancer Epidemiology, vol. 63, 101615. https://doi.org/10.1016/j.canep.2019.101615

TY - JOUR

T1 - Age at start of using tobacco on the risk of head and neck cancer

T2 - Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

AU - Chang, Chun Pin

AU - Chang, Shen Chih

AU - Chuang, Shu Chun

AU - Berthiller, Julien

AU - Ferro, Gilles

AU - Matsuo, Keitaro

AU - Wünsch-Filho, Victor

AU - Toporcov, Tatiana N.

AU - de Carvalho, Marcos Brasilino

AU - La Vecchia, Carlo

AU - Olshan, Andrew F.

AU - Zevallos, Jose P.

AU - Serraino, Diego

AU - Muscat, Joshua

AU - Sturgis, Erich M.

AU - Li, Guojun

AU - Morgenstern, Hal

AU - Levi, Fabio

AU - Dal Maso, Luigino

AU - Smith, Elaine

AU - Kelsey, Karl

AU - McClean, Michael

AU - Vaughan, Thomas L.

AU - Lazarus, Philip

AU - Ramroth, Heribert

AU - Chen, Chu

AU - Schwartz, Stephen M.

AU - Winn, Deborah M.

AU - Bosetti, Cristina

AU - Edefonti, Valeria

AU - Garavello, Werner

AU - Negri, Eva

AU - Hayes, Richard B.

AU - Purdue, Mark P.

AU - Boccia, Stefania

AU - Cadoni, Gabriella

AU - Shangina, Oxana

AU - Koifman, Rosalina

AU - Curado, Maria Paula

AU - Vilensky, Marta

AU - Swiatkowska, Beata

AU - Herrero, Rolando

AU - Franceschi, Silvia

AU - Benhamou, Simone

AU - Fernandez, Leticia

AU - Menezes, Ana M.B.

AU - Daudt, Alexander W.

AU - Mates, Dana

AU - Schantz, Stimson

AU - Yu, Guo Pei

AU - Lissowska, Jolanta

AU - Brenner, Hermann

AU - Fabianova, Eleonora

AU - Rudnai, Peter

AU - Brennan, Paul

AU - Boffetta, Paolo

AU - Zhang, Zuo Feng

AU - Hashibe, Mia

AU - Lee, Yuan Chin Amy

N1 - Funding Information: This pooled analysis was supported by grants National Cancer Institute (NCI) R03CA113157 , National Institute of Dental and Craniofacial Research (NIDCR) R03DE016611 from the National Institutes of Health (NIH). Shen-Chih Chang was supported by a Special Training Award from the International Agency for Research on Cancer . The Aviano and Italy Multicenter studies were supported by Italian Association for Research on Cancer (AIRC) , Italian League Against Cancer , and Italian Ministry of Research . The Boston study was supported by grants R01CA078609 and R01CA100679 from the National Institutes of Health . The Central Europe study was supported by grant IC15- CT98-0332 from World Cancer Research Fund and the European Commission INCO-COPERNICUS Program . The France (1987–1992) study was supported by grant KFS1069-09-2000 from Swiss League against Cancer , grant FOR381.88 from Fribourg League against Cancer , grant AKT 617 from Swiss Cancer Research and grant 88D28 from Gustave-Roussy Institute . The Germany-Heidelberg study was supported by grant 01GB9702/3 from German Ministry of Education and Research . The Germany-Saarland study was supported by Ministry of Science, Research and Arts Baden-Wurttemberg . The Houston study was supported by grants R01ES11740 and R01CA100264 from the National Institutes of Health. The International Multicenter study was supported by grants FIS 97/0024 and FIS 97/0662 from Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government , BAE 01/5013 from International Union Against Cancer (UICC) , and Yamagiwa-Yoshida Memorial International Cancer Study Grant . The Iowa study was supported by grants NIDCR R01DE011979 , NIDCR R01DE013110 and FIRCA TW001500 from National Institutes of Health and was supported by Veterans Affairs Merit Review Funds . The Japan (2001–2005) study was supported by grant 17015052 from Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan , and grant H20-002 from the Ministry of Health, Labor and Welfare of Japan . The Latin America study was supported from grant 01/01768-2 from Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina , IMIM (Barcelona) , Fundaco de Amparo a` Pesquisa no Estado de Sao Paulo (FAPESP) , and grant IC18-CT97-0222 from European Commission . The Los Angeles study was supported by grants P50CA090388 , R01DA011386 , R03CA077954 , T32CA009142 , U01CA096134 and R21ES011667 from the National Institutes of Health, and was supported by the Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center . The Milan study was supported by the Italian Association for Cancer Research . The MSKCC was supported by grant R01CA051845 from the National Institutes of Health. The New York Multicenter study was supported by grants P01CA068384 and K07CA104231 from the National Institutes of Health. The North Carolina (1994–1997) and North Carolina (2002–2006) studies were supported by grant R01CA061188 from the National Institutes of Health, and grant P30ES010126 from the National Institute of Environmental Health Sciences . The Puerto Rico study was jointly funded by National Cancer Institute (NCI) and National Institute of Dental and Craniofacial Research (NIDCR) intramural programs, National Institutes of Health. The Rome study was supported by the Italian Association for Cancer Research (AIRC). The Sao Paolo study was supported by grant 10/51168-0 from the State of São Paulo Research Foundation (FAPESP). The Seattle (1985–1995) study was supported by R01CA048896 and R01DE012609 from the National Institutes of Health. The Seattle-LEO study was supported by R01CA030022 from the National Institutes of Health. The Switzerland study was supported by grants KFS-700 and OCS-1633 from Swiss League against Cancer and the Swiss Research against Cancer/Oncosuisse . The Tampa study was supported by grants P01CA068384 , K07CA104231 and R01DE013158 from the National Institutes of Health. The US Multicenter study was supported by the Intramural Program of the National Cancer Institute (NCI), National Institutes of Health. Publisher Copyright: © 2019 Elsevier Ltd

PY - 2019/12

Y1 - 2019/12

N2 - Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR<10 years vs. ≥30 years: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR<10 years vs. ≥30 years: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.

AB - Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR<10 years vs. ≥30 years: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR<10 years vs. ≥30 years: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.

KW - Age at start of tobacco use

KW - Head and neck cancer

KW - Hypopharyngeal cancer

KW - Laryngeal cancer

KW - Oral cancer

KW - Oropharyngeal cancer

UR - http://www.scopus.com/inward/record.url?scp=85072785945&partnerID=8YFLogxK

U2 - 10.1016/j.canep.2019.101615

DO - 10.1016/j.canep.2019.101615

M3 - Article

C2 - 31586822

AN - SCOPUS:85072785945

SN - 1877-7821

VL - 63

JO - Cancer Epidemiology

JF - Cancer Epidemiology

M1 - 101615

ER -

Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

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