African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States

Talha Badar; Parameswaran Hari; Omar Dávila; Raphael Fraser; Baldeep Wirk; Binod Dhakal; Cesar O. Freytes; Cesar Rodriguez Valdes; Cindy Lee; David H. Vesole; Ehsan Malek; Gerhard C. Hildebrandt; Heather Landau; Hemant S. Murthy; Hillard M. Lazarus; Jesus G. Berdeja; Kenneth R. Meehan; Melhem Solh; Miguel Angel Diaz; Mohamed A. Kharfan-Dabaja; Natalie S. Callander; Nosha Farhadfar; Qaiser Bashir; Rammurti T. Kamble; Ravi Vij; Reinhold Munker; Robert A. Kyle; Saurabh Chhabra; Shahrukh Hashmi; Siddhartha Ganguly; Sundar Jagannath; Taiga Nishihori; Yago Nieto; Shaji Kumar; Nina Shah; Anita D’Souza

doi:10.1002/cncr.33208

African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States

Talha Badar, Parameswaran Hari, Omar Dávila, Raphael Fraser, Baldeep Wirk, Binod Dhakal, Cesar O. Freytes, Cesar Rodriguez Valdes, Cindy Lee, David H. Vesole, Ehsan Malek, Gerhard C. Hildebrandt, Heather Landau, Hemant S. Murthy, Hillard M. Lazarus, Jesus G. Berdeja, Kenneth R. Meehan, Melhem Solh, Miguel Angel Diaz, Mohamed A. Kharfan-DabajaNatalie S. Callander, Nosha Farhadfar, Qaiser Bashir, Rammurti T. Kamble, Ravi Vij, Reinhold Munker, Robert A. Kyle, Saurabh Chhabra, Shahrukh Hashmi, Siddhartha Ganguly, Sundar Jagannath, Taiga Nishihori, Yago Nieto, Shaji Kumar, Nina Shah, Anita D’Souza

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18 Scopus citations

Abstract

Background: Multiple myeloma (MM) with the translocation t(11;14) may have inferior outcomes in comparison with other standard-risk MM, and it has been suggested to portend a worse prognosis in African Americans in comparison with Whites. This study used the Center for International Blood and Marrow Transplant Research (CIBMTR) database to examine the impact of t(11;14) on the clinical outcomes of patients with MM of African American and White descent. Methods: This study evaluated 3538 patients who underwent autologous hematopoietic cell transplantation (autoHCT) for MM from 2008 to 2016 and were reported to the CIBMTR. Patients were analyzed in 4 groups: African Americans with t(11;14) (n = 117), African Americans without t(11;14) (n = 968), Whites with t(11;14) (n = 266), and Whites without t(11;14) (n = 2187). Results: African Americans with t(11;14) were younger, had lower Karnofsky scores, and had more advanced stage MM with a higher Hematopoietic Cell Transplantation–Comorbidity Index (HCT-CI). Fewer African Americans with t(11;14) (21%) had a coexistent high-risk marker in comparison with Whites with t(11;14) (27%). In a multivariate analysis, race and t(11;14) had no association with progression-free survival. However, overall survival was superior among African Americans with t(11;14) in comparison with Whites with t(11;14) (hazard ratio, 0.53; 95% confidence interval, 0.30-0.93; P =.03). Survival was also associated with female sex, stage, time from diagnosis to transplant, a low HCT-CI, and receipt of maintenance. Conclusions: Race may have a differential impact on the survival of patients with t(11;14) MM who undergo autoHCT and needs to be further studied.

Original language	English
Pages (from-to)	82-92
Number of pages	11
Journal	Cancer
Volume	127
Issue number	1
DOIs	https://doi.org/10.1002/cncr.33208
State	Published - Jan 1 2020

Keywords

myeloma
outcomes
race
t(11;14)
transplant

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10.1002/cncr.33208

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Badar, T., Hari, P., Dávila, O., Fraser, R., Wirk, B., Dhakal, B., Freytes, C. O., Rodriguez Valdes, C., Lee, C., Vesole, D. H., Malek, E., Hildebrandt, G. C., Landau, H., Murthy, H. S., Lazarus, H. M., Berdeja, J. G., Meehan, K. R., Solh, M., Diaz, M. A., ... D’Souza, A. (2020). African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States. Cancer, 127(1), 82-92. https://doi.org/10.1002/cncr.33208

@article{4f99dc2542c147eeb400323e1b065bf1,

title = "African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States",

abstract = "Background: Multiple myeloma (MM) with the translocation t(11;14) may have inferior outcomes in comparison with other standard-risk MM, and it has been suggested to portend a worse prognosis in African Americans in comparison with Whites. This study used the Center for International Blood and Marrow Transplant Research (CIBMTR) database to examine the impact of t(11;14) on the clinical outcomes of patients with MM of African American and White descent. Methods: This study evaluated 3538 patients who underwent autologous hematopoietic cell transplantation (autoHCT) for MM from 2008 to 2016 and were reported to the CIBMTR. Patients were analyzed in 4 groups: African Americans with t(11;14) (n = 117), African Americans without t(11;14) (n = 968), Whites with t(11;14) (n = 266), and Whites without t(11;14) (n = 2187). Results: African Americans with t(11;14) were younger, had lower Karnofsky scores, and had more advanced stage MM with a higher Hematopoietic Cell Transplantation–Comorbidity Index (HCT-CI). Fewer African Americans with t(11;14) (21%) had a coexistent high-risk marker in comparison with Whites with t(11;14) (27%). In a multivariate analysis, race and t(11;14) had no association with progression-free survival. However, overall survival was superior among African Americans with t(11;14) in comparison with Whites with t(11;14) (hazard ratio, 0.53; 95% confidence interval, 0.30-0.93; P =.03). Survival was also associated with female sex, stage, time from diagnosis to transplant, a low HCT-CI, and receipt of maintenance. Conclusions: Race may have a differential impact on the survival of patients with t(11;14) MM who undergo autoHCT and needs to be further studied.",

keywords = "myeloma, outcomes, race, t(11;14), transplant",

author = "Talha Badar and Parameswaran Hari and Omar D{\'a}vila and Raphael Fraser and Baldeep Wirk and Binod Dhakal and Freytes, {Cesar O.} and {Rodriguez Valdes}, Cesar and Cindy Lee and Vesole, {David H.} and Ehsan Malek and Hildebrandt, {Gerhard C.} and Heather Landau and Murthy, {Hemant S.} and Lazarus, {Hillard M.} and Berdeja, {Jesus G.} and Meehan, {Kenneth R.} and Melhem Solh and Diaz, {Miguel Angel} and Kharfan-Dabaja, {Mohamed A.} and Callander, {Natalie S.} and Nosha Farhadfar and Qaiser Bashir and Kamble, {Rammurti T.} and Ravi Vij and Reinhold Munker and Kyle, {Robert A.} and Saurabh Chhabra and Shahrukh Hashmi and Siddhartha Ganguly and Sundar Jagannath and Taiga Nishihori and Yago Nieto and Shaji Kumar and Nina Shah and Anita D{\textquoteright}Souza",

note = "Publisher Copyright: {\textcopyright} 2020 American Cancer Society",

year = "2020",

month = jan,

day = "1",

doi = "10.1002/cncr.33208",

language = "English",

volume = "127",

pages = "82--92",

journal = "Cancer",

issn = "0008-543X",

number = "1",

}

Badar, T, Hari, P, Dávila, O, Fraser, R, Wirk, B, Dhakal, B, Freytes, CO, Rodriguez Valdes, C, Lee, C, Vesole, DH, Malek, E, Hildebrandt, GC, Landau, H, Murthy, HS, Lazarus, HM, Berdeja, JG, Meehan, KR, Solh, M, Diaz, MA, Kharfan-Dabaja, MA, Callander, NS, Farhadfar, N, Bashir, Q, Kamble, RT, Vij, R, Munker, R, Kyle, RA, Chhabra, S, Hashmi, S, Ganguly, S, Jagannath, S, Nishihori, T, Nieto, Y, Kumar, S, Shah, N & D’Souza, A 2020, 'African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States', Cancer, vol. 127, no. 1, pp. 82-92. https://doi.org/10.1002/cncr.33208

TY - JOUR

T1 - African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States

AU - Badar, Talha

AU - Hari, Parameswaran

AU - Dávila, Omar

AU - Fraser, Raphael

AU - Wirk, Baldeep

AU - Dhakal, Binod

AU - Freytes, Cesar O.

AU - Rodriguez Valdes, Cesar

AU - Lee, Cindy

AU - Vesole, David H.

AU - Malek, Ehsan

AU - Hildebrandt, Gerhard C.

AU - Landau, Heather

AU - Murthy, Hemant S.

AU - Lazarus, Hillard M.

AU - Berdeja, Jesus G.

AU - Meehan, Kenneth R.

AU - Solh, Melhem

AU - Diaz, Miguel Angel

AU - Kharfan-Dabaja, Mohamed A.

AU - Callander, Natalie S.

AU - Farhadfar, Nosha

AU - Bashir, Qaiser

AU - Kamble, Rammurti T.

AU - Vij, Ravi

AU - Munker, Reinhold

AU - Kyle, Robert A.

AU - Chhabra, Saurabh

AU - Hashmi, Shahrukh

AU - Ganguly, Siddhartha

AU - Jagannath, Sundar

AU - Nishihori, Taiga

AU - Nieto, Yago

AU - Kumar, Shaji

AU - Shah, Nina

AU - D’Souza, Anita

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Background: Multiple myeloma (MM) with the translocation t(11;14) may have inferior outcomes in comparison with other standard-risk MM, and it has been suggested to portend a worse prognosis in African Americans in comparison with Whites. This study used the Center for International Blood and Marrow Transplant Research (CIBMTR) database to examine the impact of t(11;14) on the clinical outcomes of patients with MM of African American and White descent. Methods: This study evaluated 3538 patients who underwent autologous hematopoietic cell transplantation (autoHCT) for MM from 2008 to 2016 and were reported to the CIBMTR. Patients were analyzed in 4 groups: African Americans with t(11;14) (n = 117), African Americans without t(11;14) (n = 968), Whites with t(11;14) (n = 266), and Whites without t(11;14) (n = 2187). Results: African Americans with t(11;14) were younger, had lower Karnofsky scores, and had more advanced stage MM with a higher Hematopoietic Cell Transplantation–Comorbidity Index (HCT-CI). Fewer African Americans with t(11;14) (21%) had a coexistent high-risk marker in comparison with Whites with t(11;14) (27%). In a multivariate analysis, race and t(11;14) had no association with progression-free survival. However, overall survival was superior among African Americans with t(11;14) in comparison with Whites with t(11;14) (hazard ratio, 0.53; 95% confidence interval, 0.30-0.93; P =.03). Survival was also associated with female sex, stage, time from diagnosis to transplant, a low HCT-CI, and receipt of maintenance. Conclusions: Race may have a differential impact on the survival of patients with t(11;14) MM who undergo autoHCT and needs to be further studied.

AB - Background: Multiple myeloma (MM) with the translocation t(11;14) may have inferior outcomes in comparison with other standard-risk MM, and it has been suggested to portend a worse prognosis in African Americans in comparison with Whites. This study used the Center for International Blood and Marrow Transplant Research (CIBMTR) database to examine the impact of t(11;14) on the clinical outcomes of patients with MM of African American and White descent. Methods: This study evaluated 3538 patients who underwent autologous hematopoietic cell transplantation (autoHCT) for MM from 2008 to 2016 and were reported to the CIBMTR. Patients were analyzed in 4 groups: African Americans with t(11;14) (n = 117), African Americans without t(11;14) (n = 968), Whites with t(11;14) (n = 266), and Whites without t(11;14) (n = 2187). Results: African Americans with t(11;14) were younger, had lower Karnofsky scores, and had more advanced stage MM with a higher Hematopoietic Cell Transplantation–Comorbidity Index (HCT-CI). Fewer African Americans with t(11;14) (21%) had a coexistent high-risk marker in comparison with Whites with t(11;14) (27%). In a multivariate analysis, race and t(11;14) had no association with progression-free survival. However, overall survival was superior among African Americans with t(11;14) in comparison with Whites with t(11;14) (hazard ratio, 0.53; 95% confidence interval, 0.30-0.93; P =.03). Survival was also associated with female sex, stage, time from diagnosis to transplant, a low HCT-CI, and receipt of maintenance. Conclusions: Race may have a differential impact on the survival of patients with t(11;14) MM who undergo autoHCT and needs to be further studied.

KW - myeloma

KW - outcomes

KW - race

KW - t(11;14)

KW - transplant

UR - http://www.scopus.com/inward/record.url?scp=85091313309&partnerID=8YFLogxK

U2 - 10.1002/cncr.33208

DO - 10.1002/cncr.33208

M3 - Article

C2 - 32966625

AN - SCOPUS:85091313309

SN - 0008-543X

VL - 127

SP - 82

EP - 92

JO - Cancer

JF - Cancer

IS - 1

ER -

African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States

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Keywords

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