Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

Rachel Wong; Julia A. Belk; Jennifer Govero; Jennifer L. Uhrlaub; Dakota Reinartz; Haiyan Zhao; John M. Errico; Lucas D'Souza; Tyler J. Ripperger; Janko Nikolich-Zugich; Mark J. Shlomchik; Ansuman T. Satpathy; Daved H. Fremont; Michael S. Diamond; Deepta Bhattacharya

doi:10.1016/j.immuni.2020.09.001

Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

Rachel Wong, Julia A. Belk, Jennifer Govero, Jennifer L. Uhrlaub, Dakota Reinartz, Haiyan Zhao, John M. Errico, Lucas D'Souza, Tyler J. Ripperger, Janko Nikolich-Zugich, Mark J. Shlomchik, Ansuman T. Satpathy, Daved H. Fremont, Michael S. Diamond, Deepta Bhattacharya

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Memory B cells respond to heterologous antigens either by molding new specificities through secondary germinal centers or by selecting preexisting clones without further affinity maturation. Wong et al. show that for flavivirus challenges, secondary germinal centers minimally contribute to recall responses. Instead, preexisting cross-reactive clones are selected from a diverse memory compartment.

Original language	English
Pages (from-to)	1078-1094.e7
Journal	Immunity
Volume	53
Issue number	5
DOIs	https://doi.org/10.1016/j.immuni.2020.09.001
State	Published - Nov 17 2020

Keywords

Dengue virus
Japanese Encephalitis virus
West Nile virus
Zika virus
flaviruses
germinal center
memory B cells
plasma cells

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10.1016/j.immuni.2020.09.001

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Wong, R., Belk, J. A., Govero, J., Uhrlaub, J. L., Reinartz, D., Zhao, H., Errico, J. M., D'Souza, L., Ripperger, T. J., Nikolich-Zugich, J., Shlomchik, M. J., Satpathy, A. T., Fremont, D. H., Diamond, M. S., & Bhattacharya, D. (2020). Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses. Immunity, 53(5), 1078-1094.e7. https://doi.org/10.1016/j.immuni.2020.09.001

Wong, Rachel ; Belk, Julia A. ; Govero, Jennifer ; Uhrlaub, Jennifer L. ; Reinartz, Dakota ; Zhao, Haiyan ; Errico, John M. ; D'Souza, Lucas ; Ripperger, Tyler J. ; Nikolich-Zugich, Janko ; Shlomchik, Mark J. ; Satpathy, Ansuman T. ; Fremont, Daved H. ; Diamond, Michael S. ; Bhattacharya, Deepta. / Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses. In: Immunity. 2020 ; Vol. 53, No. 5. pp. 1078-1094.e7.

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title = "Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses",

abstract = "Memory B cells respond to heterologous antigens either by molding new specificities through secondary germinal centers or by selecting preexisting clones without further affinity maturation. Wong et al. show that for flavivirus challenges, secondary germinal centers minimally contribute to recall responses. Instead, preexisting cross-reactive clones are selected from a diverse memory compartment.",

keywords = "Dengue virus, Japanese Encephalitis virus, West Nile virus, Zika virus, flaviruses, germinal center, memory B cells, plasma cells",

author = "Rachel Wong and Belk, {Julia A.} and Jennifer Govero and Uhrlaub, {Jennifer L.} and Dakota Reinartz and Haiyan Zhao and Errico, {John M.} and Lucas D'Souza and Ripperger, {Tyler J.} and Janko Nikolich-Zugich and Shlomchik, {Mark J.} and Satpathy, {Ansuman T.} and Fremont, {Daved H.} and Diamond, {Michael S.} and Deepta Bhattacharya",

year = "2020",

month = nov,

day = "17",

doi = "10.1016/j.immuni.2020.09.001",

language = "English",

volume = "53",

pages = "1078--1094.e7",

journal = "Immunity",

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Wong, R, Belk, JA, Govero, J, Uhrlaub, JL, Reinartz, D, Zhao, H, Errico, JM, D'Souza, L, Ripperger, TJ, Nikolich-Zugich, J, Shlomchik, MJ, Satpathy, AT, Fremont, DH , Diamond, MS & Bhattacharya, D 2020, 'Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses', Immunity, vol. 53, no. 5, pp. 1078-1094.e7. https://doi.org/10.1016/j.immuni.2020.09.001

Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses. / Wong, Rachel; Belk, Julia A.; Govero, Jennifer; Uhrlaub, Jennifer L.; Reinartz, Dakota; Zhao, Haiyan; Errico, John M.; D'Souza, Lucas; Ripperger, Tyler J.; Nikolich-Zugich, Janko; Shlomchik, Mark J.; Satpathy, Ansuman T.; Fremont, Daved H.; Diamond, Michael S.; Bhattacharya, Deepta.

In: Immunity, Vol. 53, No. 5, 17.11.2020, p. 1078-1094.e7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

AU - Wong, Rachel

AU - Belk, Julia A.

AU - Govero, Jennifer

AU - Uhrlaub, Jennifer L.

AU - Reinartz, Dakota

AU - Zhao, Haiyan

AU - Errico, John M.

AU - D'Souza, Lucas

AU - Ripperger, Tyler J.

AU - Nikolich-Zugich, Janko

AU - Shlomchik, Mark J.

AU - Satpathy, Ansuman T.

AU - Fremont, Daved H.

AU - Diamond, Michael S.

AU - Bhattacharya, Deepta

PY - 2020/11/17

Y1 - 2020/11/17

N2 - Memory B cells respond to heterologous antigens either by molding new specificities through secondary germinal centers or by selecting preexisting clones without further affinity maturation. Wong et al. show that for flavivirus challenges, secondary germinal centers minimally contribute to recall responses. Instead, preexisting cross-reactive clones are selected from a diverse memory compartment.

AB - Memory B cells respond to heterologous antigens either by molding new specificities through secondary germinal centers or by selecting preexisting clones without further affinity maturation. Wong et al. show that for flavivirus challenges, secondary germinal centers minimally contribute to recall responses. Instead, preexisting cross-reactive clones are selected from a diverse memory compartment.

KW - Dengue virus

KW - Japanese Encephalitis virus

KW - West Nile virus

KW - Zika virus

KW - flaviruses

KW - germinal center

KW - memory B cells

KW - plasma cells

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U2 - 10.1016/j.immuni.2020.09.001

DO - 10.1016/j.immuni.2020.09.001

M3 - Article

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AN - SCOPUS:85092621009

VL - 53

SP - 1078-1094.e7

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 5

ER -

Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

Abstract

Keywords

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