Affinity-Based Enrichment of Circulating Tumor Cells

Zheng Ao, Richard J. Cote, Ram H. Datar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations

Abstract

Study of CTC in cancer has always been hampered by its rare existence in blood. In this chapter, we discuss one of first principles employed to capture CTC from cancer patients’ peripheral blood—the affinity-based enrichment of CTC. We briefly discuss the different technologies utilizing antibodies to capture CTC based on specific antigen expression. Then we address the downstream molecular and functional characterization of CTC by utilizing these technologies. We also discuss the limitations of affinity-based CTC enrichment.

Original languageEnglish
Title of host publicationCurrent Cancer Research
PublisherSpringer Nature
Pages17-28
Number of pages12
DOIs
StatePublished - 2016

Publication series

NameCurrent Cancer Research
ISSN (Print)2199-2584
ISSN (Electronic)2199-2592

Keywords

  • Affinity-based cell capture
  • Circulating tumor cells
  • In vivo CTC culture
  • Molecular characterization of CTC

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