TY - JOUR
T1 - Aerobic Glycolysis as a Marker of Tumor Aggressiveness
T2 - Preliminary Data in High Grade Human Brain Tumors
AU - Vlassenko, Andrei G.
AU - McConathy, Jonathan
AU - Couture, Lars E.
AU - Su, Yi
AU - Massoumzadeh, Parinaz
AU - Leeds, Hayden S.
AU - Chicoine, Michael R.
AU - Tran, David D.
AU - Huang, Jiayi
AU - Dahiya, Sonika
AU - Marcus, Daniel S.
AU - Fouke, Sarah Jost
AU - Rich, Keith M.
AU - Raichle, Marcus E.
AU - Benzinger, Tammie L.S.
N1 - Publisher Copyright:
Copyright © 2015 Andrei G. Vlassenko et al.
PY - 2015
Y1 - 2015
N2 - Objectives. Glucose metabolism outside of oxidative phosphorylation, or aerobic glycolysis (AG), is a hallmark of active cancer cells that is not directly measured with standard 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET). In this study, we characterized tumor regions with elevated AG defined based on PET measurements of glucose and oxygen metabolism. Methods. Fourteen individuals with high-grade brain tumors underwent structural MR scans and PET measurements of cerebral blood flow (CBF), oxygen (CMRO2) and glucose (CMRGlu) metabolism, and AG, using 15O-labeled CO, O2 and H2O, and FDG, and were compared to a normative cohort of 20 age-matched individuals. Results. Elevated AG was observed in most high-grade brain tumors and it was associated with decreased CMRO2 and CBF, but not with significant changes in CMRGlu. Elevated AG was a dramatic and early sign of tumor growth associated with decreased survival. AG changes associated with tumor growth were differentiated from the effects of nonneoplastic processes such as epileptic seizures. Conclusions. Our findings demonstrate that high-grade brain tumors exhibit elevated AG as a marker of tumor growth and aggressiveness. AG may detect areas of active tumor growth that are not evident on conventional FDG PET.
AB - Objectives. Glucose metabolism outside of oxidative phosphorylation, or aerobic glycolysis (AG), is a hallmark of active cancer cells that is not directly measured with standard 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET). In this study, we characterized tumor regions with elevated AG defined based on PET measurements of glucose and oxygen metabolism. Methods. Fourteen individuals with high-grade brain tumors underwent structural MR scans and PET measurements of cerebral blood flow (CBF), oxygen (CMRO2) and glucose (CMRGlu) metabolism, and AG, using 15O-labeled CO, O2 and H2O, and FDG, and were compared to a normative cohort of 20 age-matched individuals. Results. Elevated AG was observed in most high-grade brain tumors and it was associated with decreased CMRO2 and CBF, but not with significant changes in CMRGlu. Elevated AG was a dramatic and early sign of tumor growth associated with decreased survival. AG changes associated with tumor growth were differentiated from the effects of nonneoplastic processes such as epileptic seizures. Conclusions. Our findings demonstrate that high-grade brain tumors exhibit elevated AG as a marker of tumor growth and aggressiveness. AG may detect areas of active tumor growth that are not evident on conventional FDG PET.
UR - http://www.scopus.com/inward/record.url?scp=84941729903&partnerID=8YFLogxK
U2 - 10.1155/2015/874904
DO - 10.1155/2015/874904
M3 - Article
C2 - 26424903
AN - SCOPUS:84941729903
SN - 0278-0240
VL - 2015
JO - Disease Markers
JF - Disease Markers
M1 - 874904
ER -