@article{f2e6295a53244fa3a3d1c4c1ba80e29a,
title = "Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia",
abstract = "Asthma is associated with higher rates of acute chest syndrome (ACS) and vaso-occlusive pain episodes among children with sickle cell anaemia (SCA). Aeroallergen sensitization is a risk factor for asthma. We hypothesized that aeroallergen sensitization is associated with an increased incidence of hospitalizations for ACS and pain. Participants in a multicentre, longitudinal cohort study, aged 4–18 years with SCA, underwent skin prick testing to ten aeroallergens. ACS and pain episodes were collected from birth until the end of the follow-up period. The number of positive skin tests were tested for associations with prospective rates of ACS and pain. Multivariable models demonstrated additive effects of having positive skin tests on future rates of ACS (incidence rate ratio (IRR) for each positive test 1·23, 95% confidence interval [CI] 1·11–1·36, P < 0·001). Aeroallergen sensitization was not associated with future pain (IRR 1·14, 95%CI 0·97–1·33, P = 0·11). Our study demonstrated that children with SCA and aeroallergen sensitization are at increased risk for future ACS. Future research is needed to determine whether identification of specific sensitizations and allergen avoidance and treatment reduce the risk of ACS for children with SCA.",
keywords = "Allergy, acute chest syndrome, asthma, atopy, sickle cell anaemia",
author = "Willen, {Shaina M.} and Mark Rodeghier and Strunk, {Robert C.} and Bacharier, {Leonard B.} and Rosen, {Carol L.} and Kirkham, {Fenella J.} and DeBaun, {Michael R.} and Cohen, {Robyn T.}",
note = "Funding Information: Nashville, TN) was the principal investigator for the SAC project, helped design the concepts for SAC and this manuscript, interpreted the results, and reviewed and revised the manuscript; Dr. Cohen (Department of Pediatrics, Boston University School of Medicine, Boston, MA) interpreted the data, developed the initial draft, and reviewed and revised the manuscript; and all authors approved the final manuscript as submitted. Supported in part by the National Heart, Lung, and Blood Institute: NIH 1R01HL079937 (DeBaun), Funding Information: Sleep Asthma Cohort (SAC) investigative team Washington University, St. Louis, MO: Michael DeBaun, MD, MPH (Principal Investigator), Robert Strunk, MD (Co-investigator), Joshua Field, MD, Mario Castro, MD, MPH, Ping An, MD, Mark Johnson, MD, Michael Province, PhD, Lisa Garrett, RN, CCRP, Pamela Bates, CRT, RPFT, PRSGT, Rick Talbert, RPSGT, Sabrina Lockett, RPSGT, Valerie Morgan, RRT, Yan Yan, MD, PhD, Avril Adelman, PhD, Phillip Blanks, Tinishia Greene Case Western Reserve University, Cleveland, OH: Carol Rosen, MD (Principal Investigator), Susan Redline, MD, MPH, Heather Rogers, RPSGT, Susan Surovec, BA, Dan Craven, MD, Nancy Scott, BS, REEG/EPT, RPSGT, REDT, CNIM, Sinziana Seicean, MD, MPH, Mary DeBarr, RN, BSN, Brad Casucci, MA UCL Institute of Child Health and Great Ormond Street Hospital, London, UK: Fenella Kirkham, MD, FRCPCH (Principal Investigator), Janet Stocks, PhD, Jane Kirkby, PhD, Satwinder Sahota, BSc, Liam Welsh, PhD, Ursula Johnson, RN, Aidan Laverty, MSc, MBCS, Johanna Gavlak, BSc,, Anne Yardumian, MD, FRCP, Olu Wilkey, FRCPCH, Marilyn Roberts-Harewood, MRCPCH, Anne O'Reilly Imperial College, London, UK: Irene Roberts, MD, FRCPCH, John Warner, MD, FRCPCH Hull York Medical School, UK: Avijit Kumar Datta, MD, MRCP Medical College of Wisconsin, Milwaukee, WI: Kirk Pritchard, PhD (Principal Investigator), Thom Feroah, PhD, Cheryl Hillery, MD, Keith Oldham, MD Johns Hopkins University, Baltimore, MD: James Casella, MD (Principal Investigator). Publisher Copyright: {\textcopyright} 2018 John Wiley & Sons Ltd",
year = "2018",
month = feb,
doi = "10.1111/bjh.15076",
language = "English",
volume = "180",
pages = "571--577",
journal = "British Journal of Haematology",
issn = "0007-1048",
number = "4",
}