Adverse side-effects associated with G-CSF in patients with chronic myeloid leukemia undergoing allogeneic peripheral blood stem cell transplantation

H. Khoury, D. Adkins, R. Brown, R. Vij, P. Westervelt, K. Trinkaus, L. T. Goodnough, J. F. DiPersio

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Administration of the myeloid growth factor G-CSF after allogeneic hematopoietic stem cell transplantation is usually well tolerated, and associated with rapid hematopoietic engraftment, We report a high incidence (50%) of side-effects associated with post-transplant G-CSF in patients with chronic phase chronic myeloid leukemia undergoing allogeneic HLA-identical sibling peripheral blood stem cell transplantation. One or more of the following signs and symptoms were observed shortly after the subcutaneous injection of G-CSF: dyspnea, chest pain, nausea, hypoxemia, diaphoresis, anaphylaxis, syncope and flushing. These reactions led to discontinuation of G-CSF in the majority of patients. Predictive factors could not be identified, and the underlying mechanism leading to these reactions is unknown.

Original languageEnglish
Pages (from-to)1197-1201
Number of pages5
JournalBone Marrow Transplantation
Volume25
Issue number11
DOIs
StatePublished - Jan 1 2000

Keywords

  • BMT
  • C-CSF
  • CML
  • Side-effects

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