Adverse facial edema associated with off-label use of recombinant human bone morphogenetic protein-2 in cranial reconstruction for craniosynostosis: Case report

M. Mohsin Shah, Matthew D. Smyth, Albert S. Woo

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The authors present a case of scalp and facial edema following craniofacial reconstruction for metopic craniosynostosis in which recombinant human bone morphogenetic protein-2 (rhBMP-2) was used to treat cranial defects related to the frontoorbital reconstruction. The extent of swelling, the onset, and duration were unusual for such cases and suggested a possible role of rhBMP-2 in inducing a local inflammatory response. The edema rapidly resolved after the patient underwent surgery to remove the rhBMP-2 implants.

Original languageEnglish
Pages (from-to)255-257
Number of pages3
JournalJournal of Neurosurgery: Pediatrics
Volume1
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Bone morphogenetic protein
  • Craniofacial surgery
  • Craniosynostosis repair
  • Metopic synostosis

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