Adventures in spacetime: circadian rhythms and the dynamics of protein catabolism

Mikhail Ryzhikov, Anna Ehlers, Jeffrey A. Haspel

Research output: Contribution to journalComment/debate

Abstract

Circadian rhythms help cells to organize complex processes, but how they shape the kinetics of protein catabolism is unclear. In a recent paper, we employed proteomics to map daily biological rhythms in autophagic flux in mouse liver, and correlated these rhythms with proteasome activity. We also explored the effect of inflammation caused by endotoxin on autophagy dynamics. Our data provide insight into how circadian rhythms serve as a framework for connecting the spatial, temporal, and metabolic aspects of autophagy at a system-wide level. Our observations also have implications for how to optimize autophagy-directed therapies in patients.

Original languageEnglish
Pages (from-to)1115-1116
Number of pages2
JournalAutophagy
Volume15
Issue number6
DOIs
StatePublished - Jun 3 2019

Keywords

  • Autophagy
  • circadian rhythms
  • endotoxin
  • inflammation
  • macroautophagy
  • proteasome
  • proteomics

Fingerprint Dive into the research topics of 'Adventures in spacetime: circadian rhythms and the dynamics of protein catabolism'. Together they form a unique fingerprint.

  • Cite this