Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells

Leonardo Velazco-Cruz; Madeleine M. Goedegebuure; Jeffrey R. Millman

doi:10.3389/fbioe.2020.00786

Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells

Leonardo Velazco-Cruz
, Madeleine M. Goedegebuure
, Jeffrey R. Millman

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human pluripotent stem cells (hPSC). In 2014, two groups generated the first in vitro-differentiated glucose-responsive SC-β cells, but their functional maturation at the time was low. This review will discuss recent advances in the engineering of SC-β cells to understand and improve SC-β cell differentiation and functional maturation, particularly new differentiation strategies achieving dynamic glucose-responsive insulin secretion with rapid correction to normoglycemia when transplanted into diabetic mice.

Original language	English
Article number	786
Journal	Frontiers in Bioengineering and Biotechnology
Volume	8
DOIs	https://doi.org/10.3389/fbioe.2020.00786
State	Published - Jul 9 2020

Keywords

diabetes
differentiation
pluripotent
stem cells
transplantation

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title = "Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells",

abstract = "Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human pluripotent stem cells (hPSC). In 2014, two groups generated the first in vitro-differentiated glucose-responsive SC-β cells, but their functional maturation at the time was low. This review will discuss recent advances in the engineering of SC-β cells to understand and improve SC-β cell differentiation and functional maturation, particularly new differentiation strategies achieving dynamic glucose-responsive insulin secretion with rapid correction to normoglycemia when transplanted into diabetic mice.",

keywords = "diabetes, differentiation, pluripotent, stem cells, transplantation",

author = "Leonardo Velazco-Cruz and Goedegebuure, \{Madeleine M.\} and Millman, \{Jeffrey R.\}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Velazco-Cruz, Goedegebuure and Millman.",

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doi = "10.3389/fbioe.2020.00786",

language = "English",

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AU - Velazco-Cruz, Leonardo

AU - Goedegebuure, Madeleine M.

AU - Millman, Jeffrey R.

PY - 2020/7/9

Y1 - 2020/7/9

N2 - Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human pluripotent stem cells (hPSC). In 2014, two groups generated the first in vitro-differentiated glucose-responsive SC-β cells, but their functional maturation at the time was low. This review will discuss recent advances in the engineering of SC-β cells to understand and improve SC-β cell differentiation and functional maturation, particularly new differentiation strategies achieving dynamic glucose-responsive insulin secretion with rapid correction to normoglycemia when transplanted into diabetic mice.

AB - Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human pluripotent stem cells (hPSC). In 2014, two groups generated the first in vitro-differentiated glucose-responsive SC-β cells, but their functional maturation at the time was low. This review will discuss recent advances in the engineering of SC-β cells to understand and improve SC-β cell differentiation and functional maturation, particularly new differentiation strategies achieving dynamic glucose-responsive insulin secretion with rapid correction to normoglycemia when transplanted into diabetic mice.

KW - diabetes

KW - differentiation

KW - pluripotent

KW - stem cells

KW - transplantation

UR - https://www.scopus.com/pages/publications/85088437948

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DO - 10.3389/fbioe.2020.00786

M3 - Review article

C2 - 32733873

AN - SCOPUS:85088437948

SN - 2296-4185

VL - 8

JO - Frontiers in Bioengineering and Biotechnology

JF - Frontiers in Bioengineering and Biotechnology

M1 - 786

ER -

Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells

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Keywords

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