Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells

Leonardo Velazco-Cruz, Madeleine M. Goedegebuure, Jeffrey R. Millman

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human pluripotent stem cells (hPSC). In 2014, two groups generated the first in vitro-differentiated glucose-responsive SC-β cells, but their functional maturation at the time was low. This review will discuss recent advances in the engineering of SC-β cells to understand and improve SC-β cell differentiation and functional maturation, particularly new differentiation strategies achieving dynamic glucose-responsive insulin secretion with rapid correction to normoglycemia when transplanted into diabetic mice.

Original languageEnglish
Article number786
JournalFrontiers in Bioengineering and Biotechnology
Volume8
DOIs
StatePublished - Jul 9 2020

Keywords

  • diabetes
  • differentiation
  • pluripotent
  • stem cells
  • transplantation

Fingerprint Dive into the research topics of 'Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells'. Together they form a unique fingerprint.

Cite this