TY - JOUR
T1 - Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells
AU - Velazco-Cruz, Leonardo
AU - Goedegebuure, Madeleine M.
AU - Millman, Jeffrey R.
N1 - Publisher Copyright:
© Copyright © 2020 Velazco-Cruz, Goedegebuure and Millman.
PY - 2020/7/9
Y1 - 2020/7/9
N2 - Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human pluripotent stem cells (hPSC). In 2014, two groups generated the first in vitro-differentiated glucose-responsive SC-β cells, but their functional maturation at the time was low. This review will discuss recent advances in the engineering of SC-β cells to understand and improve SC-β cell differentiation and functional maturation, particularly new differentiation strategies achieving dynamic glucose-responsive insulin secretion with rapid correction to normoglycemia when transplanted into diabetic mice.
AB - Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human pluripotent stem cells (hPSC). In 2014, two groups generated the first in vitro-differentiated glucose-responsive SC-β cells, but their functional maturation at the time was low. This review will discuss recent advances in the engineering of SC-β cells to understand and improve SC-β cell differentiation and functional maturation, particularly new differentiation strategies achieving dynamic glucose-responsive insulin secretion with rapid correction to normoglycemia when transplanted into diabetic mice.
KW - diabetes
KW - differentiation
KW - pluripotent
KW - stem cells
KW - transplantation
UR - http://www.scopus.com/inward/record.url?scp=85088437948&partnerID=8YFLogxK
U2 - 10.3389/fbioe.2020.00786
DO - 10.3389/fbioe.2020.00786
M3 - Review article
C2 - 32733873
AN - SCOPUS:85088437948
SN - 2296-4185
VL - 8
JO - Frontiers in Bioengineering and Biotechnology
JF - Frontiers in Bioengineering and Biotechnology
M1 - 786
ER -