Advances in the production, processing and microPET image quality of technetium-94m

Heather M. Bigott; Richard Laforest; Xiaodong Liu; Ananya Ruangma; Frank Wuest; Michael J. Welch

doi:10.1016/j.nucmedbio.2006.07.001

Advances in the production, processing and microPET image quality of technetium-94m

Heather M. Bigott, Richard Laforest, Xiaodong Liu, Ananya Ruangma, Frank Wuest, Michael J. Welch

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33 Scopus citations

Abstract

This work involves the production, processing and imaging of the short-lived, rarely used positron emission tomography (PET) radionuclide technetium-94m (^94mTc). Our procedures are an extension of methods reported in the literature and are detailed within. A key modification was the development of a single step that combines purification and concentration of an aqueous ^94mTc-pertechnetate solution, which both reduces processing time and increases the final concentration of the solution. Additionally, a convenient method for the direct recovery of ^94mTc into an organic solvent was developed, eliminating the solvent transfer step needed for organic syntheses using ^94mTc. Each of these advances potentially extends the scope of syntheses possible with this short-lived radionuclide. To explore the imaging potential of ^94mTc, we carried out phantom imaging studies on small-scale high-resolution PET scanners to estimate the limitations of detection associated with ^94mTc and PET. Preliminary studies demonstrate that useful images can be obtained with modern image reconstruction algorithms when using a correction for the cascade gamma ray contamination.

Original language	English
Pages (from-to)	923-933
Number of pages	11
Journal	Nuclear Medicine and Biology
Volume	33
Issue number	7
DOIs	https://doi.org/10.1016/j.nucmedbio.2006.07.001
State	Published - Oct 2006

Keywords

Image quality
MicroPET
Processing
Tc

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10.1016/j.nucmedbio.2006.07.001

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title = "Advances in the production, processing and microPET image quality of technetium-94m",

abstract = "This work involves the production, processing and imaging of the short-lived, rarely used positron emission tomography (PET) radionuclide technetium-94m (94mTc). Our procedures are an extension of methods reported in the literature and are detailed within. A key modification was the development of a single step that combines purification and concentration of an aqueous 94mTc-pertechnetate solution, which both reduces processing time and increases the final concentration of the solution. Additionally, a convenient method for the direct recovery of 94mTc into an organic solvent was developed, eliminating the solvent transfer step needed for organic syntheses using 94mTc. Each of these advances potentially extends the scope of syntheses possible with this short-lived radionuclide. To explore the imaging potential of 94mTc, we carried out phantom imaging studies on small-scale high-resolution PET scanners to estimate the limitations of detection associated with 94mTc and PET. Preliminary studies demonstrate that useful images can be obtained with modern image reconstruction algorithms when using a correction for the cascade gamma ray contamination.",

keywords = "Image quality, MicroPET, Processing, Tc",

author = "Bigott, {Heather M.} and Richard Laforest and Xiaodong Liu and Ananya Ruangma and Frank Wuest and Welch, {Michael J.}",

note = "Funding Information: We are grateful for support extended by the National Institute of Health (Grant No. PHS 5P01 HL13851) and the Department of Energy (Grant No. DE FG02 84ER60218). 94m Tc production was partially funded through NCI Grant R24 CA86307. MicroPET imaging was supported by an NIH/NCI SAIRP grant (1 R24 CA83060). We would also like to thank the Small Animal Imaging Core of the Alvin J. Siteman Cancer Center at Washington University and Barnes-Jewish Hospital in St. Louis, MO, for additional support to the microPET imaging. The Core is supported by an NCI Cancer Center Support Grant No. 1 P30 CA91842.",

year = "2006",

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AU - Laforest, Richard

AU - Liu, Xiaodong

AU - Ruangma, Ananya

AU - Wuest, Frank

AU - Welch, Michael J.

N1 - Funding Information: We are grateful for support extended by the National Institute of Health (Grant No. PHS 5P01 HL13851) and the Department of Energy (Grant No. DE FG02 84ER60218). 94m Tc production was partially funded through NCI Grant R24 CA86307. MicroPET imaging was supported by an NIH/NCI SAIRP grant (1 R24 CA83060). We would also like to thank the Small Animal Imaging Core of the Alvin J. Siteman Cancer Center at Washington University and Barnes-Jewish Hospital in St. Louis, MO, for additional support to the microPET imaging. The Core is supported by an NCI Cancer Center Support Grant No. 1 P30 CA91842.

PY - 2006/10

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N2 - This work involves the production, processing and imaging of the short-lived, rarely used positron emission tomography (PET) radionuclide technetium-94m (94mTc). Our procedures are an extension of methods reported in the literature and are detailed within. A key modification was the development of a single step that combines purification and concentration of an aqueous 94mTc-pertechnetate solution, which both reduces processing time and increases the final concentration of the solution. Additionally, a convenient method for the direct recovery of 94mTc into an organic solvent was developed, eliminating the solvent transfer step needed for organic syntheses using 94mTc. Each of these advances potentially extends the scope of syntheses possible with this short-lived radionuclide. To explore the imaging potential of 94mTc, we carried out phantom imaging studies on small-scale high-resolution PET scanners to estimate the limitations of detection associated with 94mTc and PET. Preliminary studies demonstrate that useful images can be obtained with modern image reconstruction algorithms when using a correction for the cascade gamma ray contamination.

AB - This work involves the production, processing and imaging of the short-lived, rarely used positron emission tomography (PET) radionuclide technetium-94m (94mTc). Our procedures are an extension of methods reported in the literature and are detailed within. A key modification was the development of a single step that combines purification and concentration of an aqueous 94mTc-pertechnetate solution, which both reduces processing time and increases the final concentration of the solution. Additionally, a convenient method for the direct recovery of 94mTc into an organic solvent was developed, eliminating the solvent transfer step needed for organic syntheses using 94mTc. Each of these advances potentially extends the scope of syntheses possible with this short-lived radionuclide. To explore the imaging potential of 94mTc, we carried out phantom imaging studies on small-scale high-resolution PET scanners to estimate the limitations of detection associated with 94mTc and PET. Preliminary studies demonstrate that useful images can be obtained with modern image reconstruction algorithms when using a correction for the cascade gamma ray contamination.

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KW - Processing

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Advances in the production, processing and microPET image quality of technetium-94m

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