TY - JOUR
T1 - Advances in Screening for Radiation-Associated Cardiotoxicity in Cancer Patients
AU - Schiffer, Walter
AU - Pedersen, Lauren N.
AU - Lui, Matthew
AU - Bergom, Carmen
AU - Mitchell, Joshua D.
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/11
Y1 - 2023/11
N2 - Purpose of Review: Radiation is foundational to the treatment of cancer and improves overall survival. Yet, it is important to recognize the potential cardiovascular effects of radiation therapy and how to best minimize or manage them. Screening—both through imaging and with biomarkers—can potentially identify cardiovascular effects early, allowing for prompt initiation of treatment to mitigate late effects. Recent Findings: Cardiac echocardiography, magnetic resonance imaging (MRI), computed tomography, and measurements of troponin and natriuretic peptides serve as the initial screening tests of choice for RICD. Novel imaging applications, including positron emission tomography and specific MRI parameters, and biomarker testing, including myeloperoxidase, growth differentiation factor 15, galectin 3, micro-RNA, and metabolomics, hold promise for earlier detection and more specific characterization of RICD. Summary: Advances in imaging and novel applications of biomarkers have potential to identify subclinical RICD and may reveal opportunities for early intervention. Further research is needed to elucidate optimal imaging screening modalities, biomarkers, and surveillance strategies.
AB - Purpose of Review: Radiation is foundational to the treatment of cancer and improves overall survival. Yet, it is important to recognize the potential cardiovascular effects of radiation therapy and how to best minimize or manage them. Screening—both through imaging and with biomarkers—can potentially identify cardiovascular effects early, allowing for prompt initiation of treatment to mitigate late effects. Recent Findings: Cardiac echocardiography, magnetic resonance imaging (MRI), computed tomography, and measurements of troponin and natriuretic peptides serve as the initial screening tests of choice for RICD. Novel imaging applications, including positron emission tomography and specific MRI parameters, and biomarker testing, including myeloperoxidase, growth differentiation factor 15, galectin 3, micro-RNA, and metabolomics, hold promise for earlier detection and more specific characterization of RICD. Summary: Advances in imaging and novel applications of biomarkers have potential to identify subclinical RICD and may reveal opportunities for early intervention. Further research is needed to elucidate optimal imaging screening modalities, biomarkers, and surveillance strategies.
KW - Biomarkers
KW - Cancer
KW - Cardio-oncology
KW - Cardiotoxicity
KW - Radiation
KW - Risk prediction
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=85173776109&partnerID=8YFLogxK
U2 - 10.1007/s11886-023-01971-x
DO - 10.1007/s11886-023-01971-x
M3 - Review article
C2 - 37796395
AN - SCOPUS:85173776109
SN - 1523-3782
VL - 25
SP - 1589
EP - 1600
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 11
ER -