Advances in preclinical research models of radiation-induced cardiac toxicity

Rachel A. Schlaak, Gopika Senthilkumar, Marjan Boerma, Carmen Bergom

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving RT. As the number of cancer survivors increases, the short-and long-term side effects of cancer therapy are of growing concern. Side effects of RT for thoracic tumors, notably cardiac and pulmonary toxicities, can cause morbidity and mortality in long-term cancer survivors. An understanding of the biological pathways and mechanisms involved in normal tissue toxicity from RT will improve future cancer treatments by reducing the risk of long-term side effects. Many of these mechanistic studies are performed in animal models of radiation exposure. In this area of research, the use of small animal image-guided RT with treatment planning systems that allow more accurate dose determination has the potential to revolutionize knowledge of clinically relevant tumor and normal tissue radiobiology. However, there are still a number of challenges to overcome to optimize such radiation delivery, including dose verification and calibration, determination of doses received by adjacent normal tissues that can affect outcomes, and motion management and identifying variation in doses due to animal heterogeneity. In addition, recent studies have begun to determine how animal strain and sex affect normal tissue radiation injuries. This review article discusses the known and potential benefits and caveats of newer technologies and methods used for small animal radiation delivery, as well as how the choice of animal models, including variables such as species, strain, and age, can alter the severity of cardiac radiation toxicities and impact their clinical relevance.

Original languageEnglish
Article number415
JournalCancers
Volume12
Issue number2
DOIs
StatePublished - Feb 2020

Keywords

  • Cardiopulmonary toxicity
  • Cardiotoxicity
  • Image-guided radiotherapy
  • Normal tissue toxicity
  • Radiation biology
  • Radiation-induced heart disease
  • Small animal irradiators
  • Thoracic radiation therapy

Fingerprint

Dive into the research topics of 'Advances in preclinical research models of radiation-induced cardiac toxicity'. Together they form a unique fingerprint.

Cite this