@article{39cc8bd0b230492e8eb7765594bdb7a2,
title = "Advances and gaps in SARS-CoV-2 infection models",
abstract = "AThUe:gPlolebaaslerceosnpfiormnstheattoalClhoeraodninagvlieruveslsDairseeraepsree2se0n1te9d(cCoOrrVecItDly-:19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.",
author = "C{\'e}sar Mu{\~n}oz-Fontela and Lina Widerspick and Albrecht, {Randy A.} and Martin Beer and Carroll, {Miles W.} and {de Wit}, Emmie and Diamond, {Michael S.} and Dowling, {William E.} and Funnell, {Simon G.P.} and Adolfo Garc{\'i}a-Sastre and Gerhards, {Nora M.} and {de Jong}, Rineke and Munster, {Vincent J.} and Johan Neyts and Stanley Perlman and Reed, {Douglas S.} and Richt, {Juergen A.} and Ximena Riveros-Balta and Roy, {Chad J.} and Salguero, {Francisco J.} and Michael Schotsaert and Schwartz, {Lauren M.} and Seder, {Robert A.} and Joaquim Segal{\'e}s and Vasan, {Seshadri S.} and Henao-Restrepo, {Ana Mar{\'i}a} and Barouch, {Dan H.}",
note = "Publisher Copyright: {\textcopyright} 2022 This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.",
year = "2022",
month = jan,
doi = "10.1371/journal.ppat.1010161",
language = "English",
volume = "18",
journal = "PLoS pathogens",
issn = "1553-7366",
number = "1",
}