Advancements in adenoviral based virotherapy for ovarian cancer

Kellie S. Matthews, Ronald D. Alvarez, David T. Curiel

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Ovarian cancer is a leading gynecologic malignancy with relatively grim survival statistics. There is a significant need for the development of new treatment options for this malignancy. The development of virotherapy as a treatment option for ovarian cancer has the potential to improve patient survival. Adenoviruses have multiple advantages as vectors for virotherapy including a well-understood structure and the ability to infect cells easily. We will outline the advances in virotherapy in the treatment of ovarian cancer, with particular attention directed toward adenoviral vectors.

Original languageEnglish
Pages (from-to)836-841
Number of pages6
JournalAdvanced Drug Delivery Reviews
Volume61
Issue number10
DOIs
StatePublished - Aug 10 2009

Keywords

  • Adenoviral-based
  • Chemotherapy
  • Ovarian cancer

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