Advanced material strategies for tissue engineering scaffolds

Lisa E. Freed, George C. Engelmayr, Jeffrey T. Borenstein, Franklin T. Moutos, Farshid Guilak

Research output: Contribution to journalArticle

165 Scopus citations

Abstract

Tissue engineering seeks to restore the function of diseased or damaged tissues through the use of cells and biomaterial scaffolds. It is now apparent that the next generation of functional tissue replacements will require advanced material strategies to achieve many of the important requirements for long-term success. Here, we provide representative examples of engineered skeletal and myocardial tissue constructs in which scaffolds were explicitly designed to match native tissue mechanical properties as well as to promote cell alignment We discuss recent progress in microfluidic devices that can potentially serve as tissue engineering scaffolds, since mass transport via micro vascular-like structures will be essential in the development of tissue engineered constructs on the length scale of native tissues. Given the rapid evolution of the field of tissue engineering, it is important to consider the use of advanced materials in light of the emerging role of genetics, growth factors, bioreactors, and other technologies.

Original languageEnglish
Pages (from-to)3410-3418
Number of pages9
JournalAdvanced Materials
Volume21
Issue number32-33
DOIs
StatePublished - Sep 4 2009
Externally publishedYes

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    Freed, L. E., Engelmayr, G. C., Borenstein, J. T., Moutos, F. T., & Guilak, F. (2009). Advanced material strategies for tissue engineering scaffolds. Advanced Materials, 21(32-33), 3410-3418. https://doi.org/10.1002/adma.200900303