TY - JOUR
T1 - ADVANCE
T2 - a biomedical informatics approach to investigate acute kidney injury in infants
AU - Rumpel, Jennifer A.
AU - Perazzo, Sofia
AU - Bona, Jonathan
AU - South, Andrew M.
AU - Harer, Matthew W.
AU - Liu, Daniel
AU - Starr, Michelle C.
AU - Khattab, Mona
AU - Han, Rachel
AU - Slagle, Cara
AU - Ciccia, Eileen
AU - Najaf, Tasnim
AU - Gillen, Matthew
AU - Harsono, Mimily
AU - Nada, Arwa
AU - Dwarakanath, Kiran
AU - Gogcu, Semsa
AU - Mohamed, Tahagod
AU - Stoops, Christine
AU - Bonachea, Elizabeth
AU - Revenis, Mary
AU - Roberts, Jessica
AU - Lenzini, Robert Michael
AU - Debuyserie, Anne
AU - Joseph, Catherine
AU - Murthy, Karna
AU - Ray, Patricio
AU - Schootman, Mario
AU - Nagel, Corey
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2024.
PY - 2024
Y1 - 2024
N2 - Background: Acute kidney injury (AKI) occurs in up to half of infants admitted to the neonatal intensive care unit (NICU) and is associated with increased risks of death and more days of mechanical ventilation, hospitalization, and vasopressor drug support. Our objective was to build a granular relational database to study the impact that AKI has on infants admitted to Level-IV NICUs. Methods: A relational database was created by linking data from the Children’s Hospitals Neonatal Database with AKI-focused data from electronic health records from 9 centers. Results: The current cohort consists of 24,870 infants with a median (IQR) gestational age of birth of 37 weeks (32 weeks, 39 weeks), and a median birth weight of 2.720 kg (1.750 kg, 3.310 kg). There was a male predominance with 14,214 (57%) males. In all, 2434 (9.8%) of the mothers were of Hispanic ethnicity. The maternal race breakdown of the cohort was as follows: 741 (3.0%) Asian, 5911 (24%) Black, and 14,945 (60%) White. Overall mortality was 5.8%. Conclusion: The ADVANCE relational database is an innovative research tool to rigorously study the epidemiology of AKI in a large national cohort of infants admitted to Level-IV NICUs involved in the Children’s Hospital Neonatal Consortium. Impact: We used a biomedical informatics approach to build a relational database to study acute kidney injury in infants. We highlight our methodology linking Children’s Hospital Neonatal Consortium and electronic health record data from nine neonatal intensive care units. The ADVANCE relational database is a granular and innovative research tool to study risk factors and in-hospital outcomes of acute kidney injury and mortality in a vulnerable patient population.
AB - Background: Acute kidney injury (AKI) occurs in up to half of infants admitted to the neonatal intensive care unit (NICU) and is associated with increased risks of death and more days of mechanical ventilation, hospitalization, and vasopressor drug support. Our objective was to build a granular relational database to study the impact that AKI has on infants admitted to Level-IV NICUs. Methods: A relational database was created by linking data from the Children’s Hospitals Neonatal Database with AKI-focused data from electronic health records from 9 centers. Results: The current cohort consists of 24,870 infants with a median (IQR) gestational age of birth of 37 weeks (32 weeks, 39 weeks), and a median birth weight of 2.720 kg (1.750 kg, 3.310 kg). There was a male predominance with 14,214 (57%) males. In all, 2434 (9.8%) of the mothers were of Hispanic ethnicity. The maternal race breakdown of the cohort was as follows: 741 (3.0%) Asian, 5911 (24%) Black, and 14,945 (60%) White. Overall mortality was 5.8%. Conclusion: The ADVANCE relational database is an innovative research tool to rigorously study the epidemiology of AKI in a large national cohort of infants admitted to Level-IV NICUs involved in the Children’s Hospital Neonatal Consortium. Impact: We used a biomedical informatics approach to build a relational database to study acute kidney injury in infants. We highlight our methodology linking Children’s Hospital Neonatal Consortium and electronic health record data from nine neonatal intensive care units. The ADVANCE relational database is a granular and innovative research tool to study risk factors and in-hospital outcomes of acute kidney injury and mortality in a vulnerable patient population.
UR - http://www.scopus.com/inward/record.url?scp=85200949813&partnerID=8YFLogxK
U2 - 10.1038/s41390-024-03436-5
DO - 10.1038/s41390-024-03436-5
M3 - Article
C2 - 39122822
AN - SCOPUS:85200949813
SN - 0031-3998
JO - Pediatric research
JF - Pediatric research
ER -