Adult stem cells and their niches

Francesca Ferraro, Cristina Lo Celso, David Scadden

Research output: Chapter in Book/Report/Conference proceedingChapter

62 Scopus citations

Abstract

Stem cells participate in dynamic physiologic systems that dictate the outcome of developmental events and organismal stress, Since these cells are fundamental to tissue maintenance and repair, the signals they receive play a critical role in the integrity of the organism. Much work has focused on stem cell identification and the molecular pathways involved in their regulation. Yet, we understand little about how these pathways achieve physiologically responsive stem cell functions. This chapter will review the state of our understanding of stem cells in the context of their microenvironment regarding the relation between stem cell niche dysfunction, carcinogenesis and aging.

Original languageEnglish
Title of host publicationThe Cell Biology of Stem Cells
EditorsEran Meshorer, Kathrin Plath
Pages155-168
Number of pages14
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume695
ISSN (Print)0065-2598

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  • Cite this

    Ferraro, F., Lo Celso, C., & Scadden, D. (2010). Adult stem cells and their niches. In E. Meshorer, & K. Plath (Eds.), The Cell Biology of Stem Cells (pp. 155-168). (Advances in Experimental Medicine and Biology; Vol. 695). https://doi.org/10.1007/978-1-4419-7037-4_11