Adult-Onset Subacute Sclerosing Panencephalitis With a 30-Year Latent Period

Brandon B. Holmes, Jessamyn Conell-Price, Collin J. Kreple, Davin Ashraf, John Betjemann, Nicole Rosendale

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Subacute sclerosing panencephalitis (SSPE) is a rare progressive neuroinfectious disease due to a late complication of the measles virus. The hallmark clinical features of this disease include behavioral changes, myoclonus, dementia, visual disturbances, and pyramidal and extrapyramidal signs. The presence of characteristic high-amplitude periodic complexes on electroencephalography and raised antibody titers against measles in the cerebrospinal fluid help solidify the diagnosis. We present a case of a 40-year-old patient with SSPE who initially developed ophthalmologic manifestations 30 years after the primary measles infection. This case highlights both typical and atypical features of SSPE and provides a diagnostic framework for evaluating cases that fall outside of the standard scope of this disease.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
Issue number2
StatePublished - Apr 1 2020


  • SSPE
  • encephalitis
  • measles
  • neuroinfection
  • retinitis
  • subacute sclerosing panencephalitis


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