TY - JOUR
T1 - Adult-onset still's disease
T2 - From pathophysiology to targeted therapies
AU - Mavragani, Clio P.
AU - Spyridakis, Evangelos G.
AU - Koutsilieris, Michael
PY - 2012
Y1 - 2012
N2 - Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder affecting primarily young individuals. The diagnosis is primarily clinical and necessitates the exclusion of a wide range of mimicking disorders. Given the lack of solid data in regard to the underlying pathogenetic mechanisms, treatment of AOSD has been for years largely empirical. Recent advances have revealed a pivotal role of several proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-18 (IL-18) in disease pathogenesis, giving rise to the development of new targeted therapies aiming at optimal disease control.
AB - Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder affecting primarily young individuals. The diagnosis is primarily clinical and necessitates the exclusion of a wide range of mimicking disorders. Given the lack of solid data in regard to the underlying pathogenetic mechanisms, treatment of AOSD has been for years largely empirical. Recent advances have revealed a pivotal role of several proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-18 (IL-18) in disease pathogenesis, giving rise to the development of new targeted therapies aiming at optimal disease control.
UR - https://www.scopus.com/pages/publications/84875253912
U2 - 10.1155/2012/879020
DO - 10.1155/2012/879020
M3 - Review article
AN - SCOPUS:84875253912
SN - 2090-8040
VL - 2012
JO - International Journal of Inflammation
JF - International Journal of Inflammation
M1 - 879020
ER -