Adrenal myelolipomas involved by plasma cell myeloma

Chieh Yu Lin, David Levy, John P.T. Higgins, Christian A. Kunder, Chia Sui Kao

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objectives: To report the presence and evaluate the frequency of plasma cell neoplasms within adrenal myelolipomas. Methods: Adrenal myelolipomas within our institution were reviewed for the presence of hematologic neoplasia, and a review of the literature was performed. Results: Two (9%) of 23 adrenal myelolipomas were involved by plasma cell myeloma. The patients were 71 and 81 years old, one woman and one man, with tumors measuring 7 cm and 8.5 cm, respectively. Both tumors contained large aggregates of dysplastic plasma cells occupying at least one ×10 field and demonstrated light chain restriction. Neither had an established diagnosis of plasma cell neoplasm previously. After receiving therapy, one patient exhibited a stable clinical course 1 year after diagnosis while the other died of disease 3 years later. Conclusions: We report the first two cases of adrenal myelolipoma involved by plasma cell myeloma, a rare and subtle finding that has significant clinical implications.

Original languageEnglish
Pages (from-to)406-414
Number of pages9
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - Oct 1 2018


  • Adrenal gland
  • Lymphoma
  • Myelolipoma
  • Myeloma
  • Plasma cell neoplasm


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