TY - JOUR
T1 - Adjacent and Nonadjacent Dipyrimidine Photoproducts as Intrinsic Probes of DNA Secondary and Tertiary Structure†
AU - Taylor, John Stephen
N1 - Funding Information:
This material is based upon work supported by the National Science Foundation under NSF Grant No. 2003688. Robert Hanson is also thanked for help in assigning the chirality of various photoproducts.
Publisher Copyright:
© 2022 American Society for Photobiology.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - While the photochemistry of duplex DNA has been extensively studied, the photochemistry of nonduplex DNA structures is largely unexplored. Because the structure and stereochemistry of DNA photoproducts depend on the secondary structure and conformation of the DNA precursor, they can serve as intrinsic probes of DNA structure. This review focuses on the structures and stereoisomers of pyrimidine dimer photoproducts arising from adjacent and nonadjacent pyrimidines in A, B and denatured DNA, bulge loops, G-quadruplexes and reverse Hoogsteen hairpins and methods for their detection.
AB - While the photochemistry of duplex DNA has been extensively studied, the photochemistry of nonduplex DNA structures is largely unexplored. Because the structure and stereochemistry of DNA photoproducts depend on the secondary structure and conformation of the DNA precursor, they can serve as intrinsic probes of DNA structure. This review focuses on the structures and stereoisomers of pyrimidine dimer photoproducts arising from adjacent and nonadjacent pyrimidines in A, B and denatured DNA, bulge loops, G-quadruplexes and reverse Hoogsteen hairpins and methods for their detection.
UR - http://www.scopus.com/inward/record.url?scp=85139411973&partnerID=8YFLogxK
U2 - 10.1111/php.13694
DO - 10.1111/php.13694
M3 - Review article
C2 - 35980594
AN - SCOPUS:85139411973
SN - 0031-8655
VL - 99
SP - 277
EP - 295
JO - Photochemistry and Photobiology
JF - Photochemistry and Photobiology
IS - 2
ER -