TY - JOUR
T1 - Adiposity, Hepatic Triglyceride, and Carotid Intima Media Thickness during Behavioral Weight Loss Treatment in Antipsychotic-Treated Youth
T2 - A Randomized Pilot Study
AU - Nicol, Ginger E.
AU - Kolko, Rachel
AU - Lenze, Eric J.
AU - Yingling, Michael D.
AU - Miller, J. Philip
AU - Ricchio, Amanda R.
AU - Schweiger, Julia A.
AU - Findling, Robert L.
AU - Wilfley, Denise
AU - Newcomer, John W.
N1 - Funding Information:
1Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri. 2Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania. 3Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri. 4Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland. Departments of 5Pediatrics and 6Medicine, Washington University School of Medicine, St. Louis, Missouri. 7Thriving Mind South Florida Behavioral Health Network, Miami, Florida. Funding: This work reports on the primary outcomes of a career development award, funded by the National Institutes of Mental Health (NIMH, MH092435). This research was also supported by the Healthy Mind Lab at Washington University, the Sidney R. Baer, Jr. Foundation, by Grant Number P30DK056341 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Grant Number UL1RR024992 from the National Center for Research Resources (NCRR), a component of the NIH and NIH Roadmap for Medical Research, and the Taylor Family Institute for Innovative Psychiatric Research. Prior presentation: This work was presented at the annual American College of Neuropsychopharmacology Annual Meeting, Palm Springs, CA, December 2017, and at the American Academy of Child & Adolescent Psychiatry Annual Meeting, Seattle, WA, October 2018.
Publisher Copyright:
© 2019, Mary Ann Liebert, Inc.
PY - 2019/8
Y1 - 2019/8
N2 - Objectives: The purpose of this pilot study was to evaluate changes in adiposity, carotid intima media thickness (CIMT), and hepatic fat content measured via magnetic resonance imaging-estimated hepatic proton density fat fraction (PDFF) in antipsychotic (AP)-treated youth versus nonpsychiatric (NP) participants during participation in a 16-week behavioral weight loss (BWL) intervention. Subjects/Methods: Overweight/obese AP-treated youth (n = 26) were randomized 2:1 to weekly treatment versus recommended care (RC) over 16 weeks. NP controls (n = 21) were assigned to weekly treatment. Dual-energy X-ray absorptiometry (DEXA)-measured adiposity, CIMT, and PDFF were measured at baseline and 16 weeks. Analyses assessed group differences in the effect of BWL on adiposity, CIMT, and PDFF. Results: BWL was well tolerated in both AP-treated and NP groups. DEXA-measured fat decreased significantly in the NP group (F[1,16] = 11.81, p = 0.003), with modest improvements in adiposity and hepatic fat in the AP-treated group, while an increase in adiposity was observed in the RC group. Significant differences in endpoint DEXA total fat (F[2,34] = 4.81, p = 0.01) and PDFF (F[2,30] = 3.60, p = 0.04) occurred across treatment groups, explained by larger improvements in NP versus RC youth in DEXA total fat (p = 0.03) and PDFF (p = 0.04). Conclusions: Intensive, family-based BWL treatment can improve whole-body adiposity and liver fat in obese youth, with decreases or attenuation of additional fat gain observed in AP-treated youth.
AB - Objectives: The purpose of this pilot study was to evaluate changes in adiposity, carotid intima media thickness (CIMT), and hepatic fat content measured via magnetic resonance imaging-estimated hepatic proton density fat fraction (PDFF) in antipsychotic (AP)-treated youth versus nonpsychiatric (NP) participants during participation in a 16-week behavioral weight loss (BWL) intervention. Subjects/Methods: Overweight/obese AP-treated youth (n = 26) were randomized 2:1 to weekly treatment versus recommended care (RC) over 16 weeks. NP controls (n = 21) were assigned to weekly treatment. Dual-energy X-ray absorptiometry (DEXA)-measured adiposity, CIMT, and PDFF were measured at baseline and 16 weeks. Analyses assessed group differences in the effect of BWL on adiposity, CIMT, and PDFF. Results: BWL was well tolerated in both AP-treated and NP groups. DEXA-measured fat decreased significantly in the NP group (F[1,16] = 11.81, p = 0.003), with modest improvements in adiposity and hepatic fat in the AP-treated group, while an increase in adiposity was observed in the RC group. Significant differences in endpoint DEXA total fat (F[2,34] = 4.81, p = 0.01) and PDFF (F[2,30] = 3.60, p = 0.04) occurred across treatment groups, explained by larger improvements in NP versus RC youth in DEXA total fat (p = 0.03) and PDFF (p = 0.04). Conclusions: Intensive, family-based BWL treatment can improve whole-body adiposity and liver fat in obese youth, with decreases or attenuation of additional fat gain observed in AP-treated youth.
KW - antipsychotic
KW - child psychiatry
KW - obesity
KW - weight loss
UR - http://www.scopus.com/inward/record.url?scp=85069952092&partnerID=8YFLogxK
U2 - 10.1089/cap.2018.0120
DO - 10.1089/cap.2018.0120
M3 - Article
C2 - 30994376
AN - SCOPUS:85069952092
SN - 1044-5463
VL - 29
SP - 439
EP - 447
JO - Journal of Child and Adolescent Psychopharmacology
JF - Journal of Child and Adolescent Psychopharmacology
IS - 6
ER -