TY - JOUR
T1 - Adipose tissue stem cells
T2 - The great WAT hope
AU - Cawthorn, William P.
AU - Scheller, Erica L.
AU - MacDougald, Ormond A.
N1 - Funding Information:
O.A.M is supported by grants from the National Institutes of Health (DK51563, DK62876 and DK92759) and W.P.C. is supported by a Postdoctoral Research Fellowship from the Royal Commission for the Exhibition of 1851 (United Kingdom).
PY - 2012/6
Y1 - 2012/6
N2 - The past decade has witnessed an explosion in research into adipose tissue stem cells (ASCs), facilitated by their ease of isolation from white adipose tissue (WAT) and fueled by their therapeutic potential. Recent developments have extended ASC multipotency to include endodermal and ectodermal cell types, as well as the generation of induced pluripotent stem cells. This expanding multipotency has been paralleled by burgeoning translational applications, ranging from tissue engineering to anti-cancer therapy, that are currently subject to clinical trials. However, this promise is tempered by potential pitfalls, such as tumorigenicity, and is further undermined by lingering uncertainties regarding the precise identity of ASCs. Confronting these issues will be essential if we are to bypass the pitfalls and develop the promises of ASCs.
AB - The past decade has witnessed an explosion in research into adipose tissue stem cells (ASCs), facilitated by their ease of isolation from white adipose tissue (WAT) and fueled by their therapeutic potential. Recent developments have extended ASC multipotency to include endodermal and ectodermal cell types, as well as the generation of induced pluripotent stem cells. This expanding multipotency has been paralleled by burgeoning translational applications, ranging from tissue engineering to anti-cancer therapy, that are currently subject to clinical trials. However, this promise is tempered by potential pitfalls, such as tumorigenicity, and is further undermined by lingering uncertainties regarding the precise identity of ASCs. Confronting these issues will be essential if we are to bypass the pitfalls and develop the promises of ASCs.
UR - https://www.scopus.com/pages/publications/84861664236
U2 - 10.1016/j.tem.2012.01.003
DO - 10.1016/j.tem.2012.01.003
M3 - Review article
C2 - 22417866
AN - SCOPUS:84861664236
SN - 1043-2760
VL - 23
SP - 270
EP - 277
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 6
ER -