Adipose tissue stem cells meet preadipocyte commitment: Going back to the future

William P. Cawthorn, Erica L. Scheller, Ormond A. MacDougald

Research output: Contribution to journalReview articlepeer-review

276 Scopus citations

Abstract

White adipose tissue (WAT) is perhaps the most plastic organ in the body, capable of regeneration following surgical removal and massive expansion or contraction in response to altered energy balance. Research conducted for over 70 years has investigated adipose tissue plasticity on a cellular level, spurred on by the increasing burden that obesity and associated diseases are placing on public health globally. This work has identified committed preadipocytes in the stromal vascular fraction of adipose tissue and led to our current understanding that adipogenesis is important not only for WAT expansion, but also for maintenance of adipocyte numbers under normal metabolic states. At the turn of the millenium, studies investigating preadipocyte differentiation collided with developments in stem cell research, leading to the discovery of multipotent stem cells within WAT. Such adipose tissue-derived stem cells (ASCs) are capable of differentiating into numerous cell types of both mesodermal and nonmesodermal origin, leading to their extensive investigation from a therapeutic and tissue engineering perspective. However, the insights gained through studying ASCs have also contributed to more-recent progress in attempts to better characterize committed preadipocytes in adipose tissue. Thus, ASC research has gone back to its roots, thereby expanding our knowledge of preadipocyte commitment and adipose tissue biology.

Original languageEnglish
Pages (from-to)227-246
Number of pages20
JournalJournal of lipid research
Volume53
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • Adipocytes
  • Bone marrow
  • Preadipocytes
  • Signal transduction

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