Adipose-derived adult stem cells: Isolation, characterization, and differentiation potential

Jeffrey M. Gimble, F. Guilak

Research output: Contribution to journalArticle

810 Scopus citations

Abstract

Adipose tissue is an abundant, accessible, and replenishable source of adult stem cells that can be isolated from liposuction waste tissue by collagenase digestion and differential centrifugation. These adipose-derived adult stem (ADAS) cells are multipotent, differentiating along the adipocyte, chondrocyte, myocyte, neuronal, and osteoblast lineages, and can serve in other capacities, such as providing hematopoietic support and gene transfer. ADAS cells have potential applications for the repair and regeneration of acute and chronically damaged tissues. Additional pre-clinical safety and efficacy studies will be needed before the promise of these cells can be fully realized.

Original languageEnglish
Pages (from-to)362-369
Number of pages8
JournalCytotherapy
Volume5
Issue number5
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Keywords

  • Adipose tissue
  • Multipotent
  • Stem cell
  • Tissue engineering

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