TY - JOUR
T1 - Adipose-derived adult stem cells
T2 - Isolation, characterization, and differentiation potential
AU - Gimble, Jeffrey M.
AU - Guilak, F.
N1 - Funding Information:
The authors acknowledge support from the following granting agencies: Artecel Sciences, Inc., the North Carolina Biotechnology Center, the Kenan Instititute for Engineering, Technology and Science, and NIH grants AR43876, AG15768, AR48182 & AR49294. Thanks also to Hani Awad, Lyndon Cooper, Geoffery Erickson, Beverly Fermor, Yuan-Di Halvorsen, Kevin Hicok, Henry Rice, Kristine Safford, Robert Storms, Quinn Wickham, and all the former members of the R&D staff at Artecel Sciences for their contributions.
PY - 2003
Y1 - 2003
N2 - Adipose tissue is an abundant, accessible, and replenishable source of adult stem cells that can be isolated from liposuction waste tissue by collagenase digestion and differential centrifugation. These adipose-derived adult stem (ADAS) cells are multipotent, differentiating along the adipocyte, chondrocyte, myocyte, neuronal, and osteoblast lineages, and can serve in other capacities, such as providing hematopoietic support and gene transfer. ADAS cells have potential applications for the repair and regeneration of acute and chronically damaged tissues. Additional pre-clinical safety and efficacy studies will be needed before the promise of these cells can be fully realized.
AB - Adipose tissue is an abundant, accessible, and replenishable source of adult stem cells that can be isolated from liposuction waste tissue by collagenase digestion and differential centrifugation. These adipose-derived adult stem (ADAS) cells are multipotent, differentiating along the adipocyte, chondrocyte, myocyte, neuronal, and osteoblast lineages, and can serve in other capacities, such as providing hematopoietic support and gene transfer. ADAS cells have potential applications for the repair and regeneration of acute and chronically damaged tissues. Additional pre-clinical safety and efficacy studies will be needed before the promise of these cells can be fully realized.
KW - Adipose tissue
KW - Multipotent
KW - Stem cell
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=0242552104&partnerID=8YFLogxK
U2 - 10.1080/14653240310003026
DO - 10.1080/14653240310003026
M3 - Article
C2 - 14578098
AN - SCOPUS:0242552104
SN - 1465-3249
VL - 5
SP - 362
EP - 369
JO - Cytotherapy
JF - Cytotherapy
IS - 5
ER -