TY - JOUR
T1 - Adipocyte fetuin-a contributes to macrophage migration into adipose tissue and polarization of macrophages
AU - Chatterjee, Priyajit
AU - Seal, Soma
AU - Mukherjee, Sandip
AU - Kundu, Rakesh
AU - Mukherjee, Sutapa
AU - Ray, Sukanta
AU - Mukhopadhyay, Satinath
AU - Majumdar, Subeer S.
AU - Bhattacharya, Samir
PY - 2013/9/27
Y1 - 2013/9/27
N2 - Background: Obesity-induced inflammation is characterized by macrophage migration and polarization; signaling regulation therein remains poorly understood. Results: Lipid-induced fetuin-A from adipose tissue acts as chemoattractant for macrophage migration and also polarizes adipose tissue M2 macrophages to proinflammatory M1 subtype. Conclusion: Adipocyte fetuin-A is a novel signaling molecule in lipid-induced tissue inflammation. Significance: These findings have revealed an unseen area of inflammation.
AB - Background: Obesity-induced inflammation is characterized by macrophage migration and polarization; signaling regulation therein remains poorly understood. Results: Lipid-induced fetuin-A from adipose tissue acts as chemoattractant for macrophage migration and also polarizes adipose tissue M2 macrophages to proinflammatory M1 subtype. Conclusion: Adipocyte fetuin-A is a novel signaling molecule in lipid-induced tissue inflammation. Significance: These findings have revealed an unseen area of inflammation.
UR - http://www.scopus.com/inward/record.url?scp=84884808904&partnerID=8YFLogxK
U2 - 10.1074/jbc.C113.495473
DO - 10.1074/jbc.C113.495473
M3 - Article
C2 - 23943623
AN - SCOPUS:84884808904
SN - 0021-9258
VL - 288
SP - 28324
EP - 28330
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 39
ER -