Adhesion GPCRs as modulators of immune cell function

Jörg Hamann, Cheng Chih Hsiao, Chang Sup Lee, Kodi S. Ravichandran, Hsi Hsien Lin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

34 Scopus citations


Immune cells express several adhesion G protein-coupled receptors (aGPCRs), including the ADGRE subfamily members EMR1 (F4/80, ADGRE1), EMR2 (ADGRE2), EMR3 (ADGRE3), EMR4 (FIRE, ADGRE4), and CD97 (ADGRE5), the ADGRB subfamily member BAI1 (ADGRB1), and the ADGRG subfamily members GPR56 (ADGRG1), GPR97 (Pb99, ADGRG3), and GPR114 (ADGRG5). Expression of these molecules in hematopoietic stem and progenitor cells, monocytes/macrophages (Mφs), dendritic cells, granulocytes, and lymphocytes depends on lineage diversification and maturation, making them suitable markers for individual leukocyte subsets (e.g., F4/80 on mouse Mφs). Recent studies revealed intriguing activities of aGPCRs in tolerance induction (EMR1), granulopoiesis (CD97), engulfment of apoptotic cells and bacteria (BAI1), hematopoietic stem cell formation (GPR56), and control of cytotoxicity (GPR56). Here, we review these findings and discuss their biological and translational implications.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
PublisherSpringer New York LLC
Number of pages22
StatePublished - Nov 1 2016

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325


  • Adhesion GPCRs
  • Granulocytes
  • Immunity
  • Macrophages
  • Phagocytosis
  • T cells


Dive into the research topics of 'Adhesion GPCRs as modulators of immune cell function'. Together they form a unique fingerprint.

Cite this