TY - CHAP
T1 - Adhesion GPCRs as modulators of immune cell function
AU - Hamann, Jörg
AU - Hsiao, Cheng Chih
AU - Lee, Chang Sup
AU - Ravichandran, Kodi S.
AU - Lin, Hsi Hsien
N1 - Publisher Copyright:
© Springer International Publishing AG 2016.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Immune cells express several adhesion G protein-coupled receptors (aGPCRs), including the ADGRE subfamily members EMR1 (F4/80, ADGRE1), EMR2 (ADGRE2), EMR3 (ADGRE3), EMR4 (FIRE, ADGRE4), and CD97 (ADGRE5), the ADGRB subfamily member BAI1 (ADGRB1), and the ADGRG subfamily members GPR56 (ADGRG1), GPR97 (Pb99, ADGRG3), and GPR114 (ADGRG5). Expression of these molecules in hematopoietic stem and progenitor cells, monocytes/macrophages (Mφs), dendritic cells, granulocytes, and lymphocytes depends on lineage diversification and maturation, making them suitable markers for individual leukocyte subsets (e.g., F4/80 on mouse Mφs). Recent studies revealed intriguing activities of aGPCRs in tolerance induction (EMR1), granulopoiesis (CD97), engulfment of apoptotic cells and bacteria (BAI1), hematopoietic stem cell formation (GPR56), and control of cytotoxicity (GPR56). Here, we review these findings and discuss their biological and translational implications.
AB - Immune cells express several adhesion G protein-coupled receptors (aGPCRs), including the ADGRE subfamily members EMR1 (F4/80, ADGRE1), EMR2 (ADGRE2), EMR3 (ADGRE3), EMR4 (FIRE, ADGRE4), and CD97 (ADGRE5), the ADGRB subfamily member BAI1 (ADGRB1), and the ADGRG subfamily members GPR56 (ADGRG1), GPR97 (Pb99, ADGRG3), and GPR114 (ADGRG5). Expression of these molecules in hematopoietic stem and progenitor cells, monocytes/macrophages (Mφs), dendritic cells, granulocytes, and lymphocytes depends on lineage diversification and maturation, making them suitable markers for individual leukocyte subsets (e.g., F4/80 on mouse Mφs). Recent studies revealed intriguing activities of aGPCRs in tolerance induction (EMR1), granulopoiesis (CD97), engulfment of apoptotic cells and bacteria (BAI1), hematopoietic stem cell formation (GPR56), and control of cytotoxicity (GPR56). Here, we review these findings and discuss their biological and translational implications.
KW - Adhesion GPCRs
KW - Granulocytes
KW - Immunity
KW - Macrophages
KW - Phagocytosis
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=84995476541&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-41523-9_15
DO - 10.1007/978-3-319-41523-9_15
M3 - Chapter
C2 - 27832495
AN - SCOPUS:84995476541
T3 - Handbook of Experimental Pharmacology
SP - 329
EP - 350
BT - Handbook of Experimental Pharmacology
PB - Springer New York LLC
ER -