Adherence to oral cancer therapy in older adults: The International Society of Geriatric Oncology (SIOG) taskforce recommendations

Anna Rachelle Mislang, Tanya M. Wildes, Ravindran Kanesvaran, Capucine Baldini, Holly M. Holmes, Ginah Nightingale, Annemarie Coolbrandt, Laura Biganzoli

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

There is an increasing trend towards using oral systemic therapy in patients with cancer. Compared to parenteral therapy, oral cancer agents offer convenience, have similar efficacy, and are preferred by patients, consequently making its use appealing in older adults. However, adherence is required to ensure its efficacy and to avoid compromising treatment outcomes, especially when the treatment goal is curative, or in case of symptomatic/rapidly progressing disease, where dose-intensity is important. This opens a new challenge for clinicians, as optimizing patient adherence is challenging, particularly due to lack of consensus and scarcity of available clinical evidence. This manuscript aims to review the impact of age-related factors on adherence, summarize the evidence on adherence, recommend methods for selecting patients suitable for oral cancer agents, and advise monitoring interventions to promote adherence to treatment.

Original languageEnglish
Pages (from-to)58-66
Number of pages9
JournalCancer Treatment Reviews
Volume57
DOIs
StatePublished - Jun 2017

Keywords

  • Adherence
  • Geriatric oncology
  • Oral cancer agents
  • Toxicity

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