The nucleotide 2′-deoxycoformycin 5′-phosphate has been enzymatically synthesized from 2′-deoxycoformycin and found to be a potent stoichiometric inhibitor of adenylate deaminase from rabbit muscle. It is shown that the inhibitor binds to the active site and may be considered as a possible transition state analog. The inhibition is time dependent which may reflect an inhibitor induced conformational change.
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Nov 14 1979|