Adenylate deaminase: Potent inhibition by 2′-deoxycoformycin 5′-phosphate

Carl Frieden, Helen R. Gilbert, Wayne H. Miller, Richard L. Miller

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The nucleotide 2′-deoxycoformycin 5′-phosphate has been enzymatically synthesized from 2′-deoxycoformycin and found to be a potent stoichiometric inhibitor of adenylate deaminase from rabbit muscle. It is shown that the inhibitor binds to the active site and may be considered as a possible transition state analog. The inhibition is time dependent which may reflect an inhibitor induced conformational change.

Original languageEnglish
Pages (from-to)278-283
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume91
Issue number1
DOIs
StatePublished - Nov 14 1979

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