Adenylate cyclase activity in the families of alcoholics is controlled by a single major gene.

E. J. Devor; C. R. Cloninger; P. L. Hoffman; B. Tabakoff

Adenylate cyclase activity in the families of alcoholics is controlled by a single major gene.

E. J. Devor, C. R. Cloninger, P. L. Hoffman, B. Tabakoff

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Abstract

The stimulated activity of platelet adenylate cyclase (AC) has been shown to be significantly lower among alcoholics compared with controls. In this report we demonstrate that stimulated platelet AC activity is under the control of a single major gene locus. Thus a sensitive biological indicator of alcoholism has been shown to be highly heritable.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.
Volume	1
State	Published - 1991

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title = "Adenylate cyclase activity in the families of alcoholics is controlled by a single major gene.",

abstract = "The stimulated activity of platelet adenylate cyclase (AC) has been shown to be significantly lower among alcoholics compared with controls. In this report we demonstrate that stimulated platelet AC activity is under the control of a single major gene locus. Thus a sensitive biological indicator of alcoholism has been shown to be highly heritable.",

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AU - Devor, E. J.

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AB - The stimulated activity of platelet adenylate cyclase (AC) has been shown to be significantly lower among alcoholics compared with controls. In this report we demonstrate that stimulated platelet AC activity is under the control of a single major gene locus. Thus a sensitive biological indicator of alcoholism has been shown to be highly heritable.

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AN - SCOPUS:0026379599

SN - 1358-6173

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JO - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.

JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.

ER -

Adenylate cyclase activity in the families of alcoholics is controlled by a single major gene.

Abstract

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