Adenovirus Strategies for Tissue-Specific Targeting

Matthew S. Beatty, David T. Curiel

Research output: Chapter in Book/Report/Conference proceedingChapter

35 Scopus citations

Abstract

Cancer gene therapy approaches have benefited greatly from the utilization of molecular-based therapeutics. Of these, adenovirus-based interventions hold much promise as a platform for targeted therapeutic delivery to tumors. However, a barrier to this progression is the lack of native adenovirus receptor expression on a variety of cancer types. As such, any adenovirus-based cancer therapy must take into consideration retargeting the vector to nonnative cellular surface receptors. Predicated upon the knowledge gained in native adenovirus biology, several strategies to transductionally retarget adenovirus have emerged. Herein, we describe the biological hurdles as well as strategies utilized in adenovirus transductional targeting, covering the progress of both adapter-based and genetic manipulation-based targeting. Additionally, we discuss recent translation of these targeting strategies into a clinical setting.

Original languageEnglish
Title of host publicationAdvances in Cancer Research
PublisherAcademic Press Inc.
Pages39-67
Number of pages29
DOIs
StatePublished - 2012

Publication series

NameAdvances in Cancer Research
Volume115
ISSN (Print)0065-230X

Keywords

  • Adapter
  • Adenovirus
  • Cancer
  • Gene therapy
  • Genetic manipulation
  • Targeting
  • Tropism

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    Beatty, M. S., & Curiel, D. T. (2012). Adenovirus Strategies for Tissue-Specific Targeting. In Advances in Cancer Research (pp. 39-67). (Advances in Cancer Research; Vol. 115). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-398342-8.00002-1