Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors

Joshua J. Short, Alexander V. Pereboev, Yosuke Kawakami, Chenthamarakshan Vasu, Mark J. Holterman, David T. Curiel

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

Most viruses exploit a variety of host cellular proteins as primary cellular attachment receptors in the context of successful execution of infection. Furthermore, many viral agents have evolved precise mechanisms to subvert host immune recognition to achieve persistence. Herein we present data indicating that adenovirus (Ad) serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors. CD80 and CD86 are co-stimulatory molecules that are present on mature dendritic cells and B lymphocytes and are involved in stimulating T-lymphocyte activation. To our knowledge, this is one of the first demonstrations of a virus utilizing immunologic accessory molecules as a primary means of cellular entry. This finding suggests a mechanism whereby viral exploitation of these proteins as receptors may achieve both goals of cellular entry and evading the immune system.

Original languageEnglish
Pages (from-to)349-359
Number of pages11
JournalVirology
Volume322
Issue number2
DOIs
StatePublished - May 1 2004
Externally publishedYes

Keywords

  • Ad
  • Ad11
  • Ad2
  • Ad3
  • Ad37
  • Ad5
  • Ad7
  • Adenovirus
  • Adenovirus serotype 11
  • Adenovirus serotype 2
  • Adenovirus serotype 3
  • Adenovirus serotype 37
  • Adenovirus serotype 5
  • Adenovirus serotype 7
  • CAR
  • CD80
  • CD86
  • Co-stimulatory molecules
  • Receptor
  • Subgroup B

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