Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

Guadalupe Bilbao; Juan L. Contreras; Huang Ge Zhang; M. Joyce Pike; Ken Overturf; Galina Mikheeva; Victor Krasnykh; David T. Curiel

doi:10.1128/jvi.73.8.6992-7000.1999

Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

Guadalupe Bilbao, Juan L. Contreras, Huang Ge Zhang, M. Joyce Pike, Ken Overturf, Galina Mikheeva, Victor Krasnykh, David T. Curiel

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

Original language	English
Pages (from-to)	6992-7000
Number of pages	9
Journal	Journal of virology
Volume	73
Issue number	8
DOIs	https://doi.org/10.1128/jvi.73.8.6992-7000.1999
State	Published - 1999

Access to Document

10.1128/jvi.73.8.6992-7000.1999

Cite this

@article{6f2dab8d91c54418ac428d00009c4ec2,

title = "Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene",

abstract = "An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.",

author = "Guadalupe Bilbao and Contreras, {Juan L.} and Zhang, {Huang Ge} and Pike, {M. Joyce} and Ken Overturf and Galina Mikheeva and Victor Krasnykh and Curiel, {David T.}",

year = "1999",

doi = "10.1128/jvi.73.8.6992-7000.1999",

language = "English",

volume = "73",

pages = "6992--7000",

journal = "Journal of virology",

issn = "0022-538X",

number = "8",

}

TY - JOUR

T1 - Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

AU - Bilbao, Guadalupe

AU - Contreras, Juan L.

AU - Zhang, Huang Ge

AU - Pike, M. Joyce

AU - Overturf, Ken

AU - Mikheeva, Galina

AU - Krasnykh, Victor

AU - Curiel, David T.

PY - 1999

Y1 - 1999

N2 - An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

AB - An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

UR - http://www.scopus.com/inward/record.url?scp=0032809227&partnerID=8YFLogxK

U2 - 10.1128/jvi.73.8.6992-7000.1999

DO - 10.1128/jvi.73.8.6992-7000.1999

M3 - Article

C2 - 10400798

AN - SCOPUS:0032809227

SN - 0022-538X

VL - 73

SP - 6992

EP - 7000

JO - Journal of virology

JF - Journal of virology

IS - 8

ER -

Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

Abstract

Access to Document

Other files and links

Fingerprint

Cite this