Abstract
An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 6992-7000 |
| Number of pages | 9 |
| Journal | Journal of virology |
| Volume | 73 |
| Issue number | 8 |
| DOIs | |
| State | Published - 1999 |