Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

Guadalupe Bilbao, Juan L. Contreras, Huang Ge Zhang, M. Joyce Pike, Ken Overturf, Galina Mikheeva, Victor Krasnykh, David T. Curiel

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Abstract

An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

Original languageEnglish
Pages (from-to)6992-7000
Number of pages9
JournalJournal of virology
Volume73
Issue number8
StatePublished - Jan 1 1999
Externally publishedYes

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    Bilbao, G., Contreras, J. L., Zhang, H. G., Pike, M. J., Overturf, K., Mikheeva, G., Krasnykh, V., & Curiel, D. T. (1999). Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene. Journal of virology, 73(8), 6992-7000.