Adenosine receptors in rat testes: Labeling with 3Hcyclohexyladenosine

Kenneth M.M. Murphy, Solomon H. Snyder

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

We have labeled adenosine receptors in rat tissues with 3HN6cyclohexyladenosine (3HCHA) and evaluated the organ distribution and drug specificity of these binding sites throughout the body. Detectable receptor concentrations are restricted to the brain and testes. Brain displays receptor levels of 9 pmoles/g wet weight of tissue while the testes display 2 pmoles/g, with all other tissues examined showing less than detectable specific binding of 3HCHA. The receptors in these two tissues appear to possess identical pharmacologic profiles with an A1 specificity for both. No change in the total number of 3HCHA binding sites is seen in testes of rats which had been hypophysectomized 14 days prior to sacrifice. This may exclude the Leydig cells as a source of adenosine receptors in the rat testes.

Original languageEnglish
Pages (from-to)917-920
Number of pages4
JournalLife Sciences
Volume28
Issue number8
DOIs
StatePublished - Feb 23 1981
Externally publishedYes

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