Adenosine Deaminase Converts Purine Riboside into an Analogue of a Reactive Intermediate: A¹³C NMR and Kinetic Study

Keyphrases

• Kinetic Study 100%
• NMR Studies 100%
• Purine 100%
• Adenosine Deaminase 100%
• Riboside 100%
• Reactive Intermediates 100%
• Chemical Shift 33%
• Binary Complexes 33%
• Slow Exchange 33%
• Protonation 33%
• Active Sites 16%
• Acid Hydrolysis 16%
• Aqueous Solution 16%
• Dissociation Rate Constant 16%
• Chloro 16%
• Sulfur 16%
• Transition State 16%
• Shift Change 16%
• Rate-determining Step 16%
• Kinetic Constants 16%
• 13C NMR Chemical Shift 16%
• Free Ligand 16%
• Base-free 16%
• 13C NMR Spectra 16%
• Tetrahedral Intermediate 16%
• Bond Breaking 16%
• Catalytic Strategies 16%
• NMR Timescale 16%
• Exchange Broadening 16%
• Carbon-halogen Bond 16%
• Standard Free Energy 16%
• Reactivity Order 16%

Biochemistry, Genetics and Molecular Biology

• Riboside 100%
• Adenosine Deaminase 100%
• Enzyme 50%
• Protonation 33%
• Active Site 16%
• Enzymatic Hydrolysis 16%
• Solution and Solubility 16%
• Dissociation Rate Constant 16%
• Aqueous Solution 16%