Addressing a vascular endothelium array with blood components using underlying microfluidic channels

Luiza I. Genes; Nicole V. Tolan; Matthew K. Hulvey; R. Scott Martin; Dana M. Spence

doi:10.1039/b712619k

Addressing a vascular endothelium array with blood components using underlying microfluidic channels

Luiza I. Genes
, Nicole V. Tolan
, Matthew K. Hulvey
, R. Scott Martin
, Dana M. Spence

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Here, we show that an array of endothelial cells, addressable by an underlying microfluidic network of channels containing red blood cells, can be employed as an in vitro model of in vivo circulation to monitor cellular communication between different cell types in the drug discovery process.

Original language	English
Pages (from-to)	1256-1259
Number of pages	4
Journal	Lab on a Chip
Volume	7
Issue number	10
DOIs	https://doi.org/10.1039/b712619k
State	Published - 2007

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10.1039/b712619k

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title = "Addressing a vascular endothelium array with blood components using underlying microfluidic channels",

abstract = "Here, we show that an array of endothelial cells, addressable by an underlying microfluidic network of channels containing red blood cells, can be employed as an in vitro model of in vivo circulation to monitor cellular communication between different cell types in the drug discovery process.",

author = "Genes, \{Luiza I.\} and Tolan, \{Nicole V.\} and Hulvey, \{Matthew K.\} and Martin, \{R. Scott\} and Spence, \{Dana M.\}",

year = "2007",

doi = "10.1039/b712619k",

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T1 - Addressing a vascular endothelium array with blood components using underlying microfluidic channels

AU - Genes, Luiza I.

AU - Tolan, Nicole V.

AU - Hulvey, Matthew K.

AU - Martin, R. Scott

AU - Spence, Dana M.

PY - 2007

Y1 - 2007

N2 - Here, we show that an array of endothelial cells, addressable by an underlying microfluidic network of channels containing red blood cells, can be employed as an in vitro model of in vivo circulation to monitor cellular communication between different cell types in the drug discovery process.

AB - Here, we show that an array of endothelial cells, addressable by an underlying microfluidic network of channels containing red blood cells, can be employed as an in vitro model of in vivo circulation to monitor cellular communication between different cell types in the drug discovery process.

UR - https://www.scopus.com/pages/publications/34748894796

U2 - 10.1039/b712619k

DO - 10.1039/b712619k

M3 - Article

C2 - 17896007

AN - SCOPUS:34748894796

SN - 1473-0197

VL - 7

SP - 1256

EP - 1259

JO - Lab on a Chip

JF - Lab on a Chip

IS - 10

ER -

Addressing a vascular endothelium array with blood components using underlying microfluidic channels

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