Adalimumab-associated optic neuritis

Jacob H. Chung; Gregory P. Van Stavern; Larry P. Frohman; Roger E. Turbin

doi:10.1016/j.jns.2006.01.012

Adalimumab-associated optic neuritis

Jacob H. Chung, Gregory P. Van Stavern, Larry P. Frohman, Roger E. Turbin

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

We present, to our knowledge, the first published cases of optic neuritis associated with adalimumab, a medication in the class of anti-tumor necrosis factor-alpha (TNF-α) antagonists. Approved in recent years by the FDA, adalimumab (Humira, Abbott Laboratories; Abbott Park, IL) is a recombinant monoclonal antibody that targets and blocks the physiologic effects of TNF. Other TNF antagonists have had associations with optic neuritis and demyelinating events.

Original language	English
Pages (from-to)	133-136
Number of pages	4
Journal	Journal of the Neurological Sciences
Volume	244
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2006.01.012
State	Published - May 15 2006

Keywords

Adalimumab
Enbrel
Etanercept
Humira
Infliximab
Optic neuritis
Remicade
Tumor necrosis factor

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10.1016/j.jns.2006.01.012

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title = "Adalimumab-associated optic neuritis",

abstract = "We present, to our knowledge, the first published cases of optic neuritis associated with adalimumab, a medication in the class of anti-tumor necrosis factor-alpha (TNF-α) antagonists. Approved in recent years by the FDA, adalimumab (Humira, Abbott Laboratories; Abbott Park, IL) is a recombinant monoclonal antibody that targets and blocks the physiologic effects of TNF. Other TNF antagonists have had associations with optic neuritis and demyelinating events.",

keywords = "Adalimumab, Enbrel, Etanercept, Humira, Infliximab, Optic neuritis, Remicade, Tumor necrosis factor",

author = "Chung, {Jacob H.} and {Van Stavern}, {Gregory P.} and Frohman, {Larry P.} and Turbin, {Roger E.}",

note = "Funding Information: This work was supported in part by an Unrestricted Grant from Research to Prevent Blindness, Inc. NY, NY; Fund for the New Jersey Blind, Newark, NJ; Lions Eye Research Foundation of New Jersey, Newark, NJ; the Eye Institute of New Jersey, Newark, NJ; and the Gene C. Coppa Memorial Fund. ",

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doi = "10.1016/j.jns.2006.01.012",

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T1 - Adalimumab-associated optic neuritis

AU - Chung, Jacob H.

AU - Van Stavern, Gregory P.

AU - Frohman, Larry P.

AU - Turbin, Roger E.

N1 - Funding Information: This work was supported in part by an Unrestricted Grant from Research to Prevent Blindness, Inc. NY, NY; Fund for the New Jersey Blind, Newark, NJ; Lions Eye Research Foundation of New Jersey, Newark, NJ; the Eye Institute of New Jersey, Newark, NJ; and the Gene C. Coppa Memorial Fund.

PY - 2006/5/15

Y1 - 2006/5/15

N2 - We present, to our knowledge, the first published cases of optic neuritis associated with adalimumab, a medication in the class of anti-tumor necrosis factor-alpha (TNF-α) antagonists. Approved in recent years by the FDA, adalimumab (Humira, Abbott Laboratories; Abbott Park, IL) is a recombinant monoclonal antibody that targets and blocks the physiologic effects of TNF. Other TNF antagonists have had associations with optic neuritis and demyelinating events.

AB - We present, to our knowledge, the first published cases of optic neuritis associated with adalimumab, a medication in the class of anti-tumor necrosis factor-alpha (TNF-α) antagonists. Approved in recent years by the FDA, adalimumab (Humira, Abbott Laboratories; Abbott Park, IL) is a recombinant monoclonal antibody that targets and blocks the physiologic effects of TNF. Other TNF antagonists have had associations with optic neuritis and demyelinating events.

KW - Adalimumab

KW - Enbrel

KW - Etanercept

KW - Humira

KW - Infliximab

KW - Optic neuritis

KW - Remicade

KW - Tumor necrosis factor

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M3 - Article

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AN - SCOPUS:33646089875

SN - 0022-510X

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SP - 133

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JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

IS - 1-2

ER -

Adalimumab-associated optic neuritis

Abstract

Keywords

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