Abstract
The effect of acute swim stress on the functional activity of the γ-aminobutyric acid (GABA) receptor/chloride ion channel was studied using an assay to measure 36chloride (36Cl-) uptake into rat brain synaptoneurosomes. Muscimol-stimulated 36Cl- uptake in cerebral cortex, hippocampus, but not cerebellum, was enhanced (increased potency and efficacy) in rats subjected to 10 min of swimming, compared to non-stressed, control rats. The effect of swim stress on the activity of the GABA receptor/Cl- ion channel was prevented by adrenalectomy.
Original language | English |
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Pages (from-to) | 151-155 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 411 |
Issue number | 1 |
DOIs | |
State | Published - May 12 1987 |
Keywords
- Chloride ion channel
- Cl flux
- Rat brain
- Stress
- Synaptoneurosome
- γ-Aminobutyric acid receptor