Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain

Rochelle D. Schwartz, Michael J. Wess, Rodrigo Labarca, Phil Skolnick, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

The effect of acute swim stress on the functional activity of the γ-aminobutyric acid (GABA) receptor/chloride ion channel was studied using an assay to measure 36chloride (36Cl-) uptake into rat brain synaptoneurosomes. Muscimol-stimulated 36Cl- uptake in cerebral cortex, hippocampus, but not cerebellum, was enhanced (increased potency and efficacy) in rats subjected to 10 min of swimming, compared to non-stressed, control rats. The effect of swim stress on the activity of the GABA receptor/Cl- ion channel was prevented by adrenalectomy.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalBrain Research
Volume411
Issue number1
DOIs
StatePublished - May 12 1987

Keywords

  • Chloride ion channel
  • Cl flux
  • Rat brain
  • Stress
  • Synaptoneurosome
  • γ-Aminobutyric acid receptor

Fingerprint

Dive into the research topics of 'Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain'. Together they form a unique fingerprint.

Cite this