TY - JOUR
T1 - Acute Rejection and Antibody-Mediated Rejection in Lung Transplantation
AU - Hachem, Ramsey R.
PY - 2017/12
Y1 - 2017/12
N2 - Despite advances in immunosuppression over the past 25 years, acute cellular rejection remains a common complication early after lung transplantation. Although acute cellular rejection has often not resulted in clinical signs or symptoms of allograft dysfunction, it has been widely recognized as a strong independent risk factor for the development of chronic rejection, emphasizing its clinical significance. In recent years, the role of humoral immunity in lung rejection has been increasingly appreciated, and antibody-mediated rejection is now recognized as a form of rejection that may result in allograft failure.
AB - Despite advances in immunosuppression over the past 25 years, acute cellular rejection remains a common complication early after lung transplantation. Although acute cellular rejection has often not resulted in clinical signs or symptoms of allograft dysfunction, it has been widely recognized as a strong independent risk factor for the development of chronic rejection, emphasizing its clinical significance. In recent years, the role of humoral immunity in lung rejection has been increasingly appreciated, and antibody-mediated rejection is now recognized as a form of rejection that may result in allograft failure.
KW - Acute rejection
KW - Antibody-mediated rejection
KW - Lung transplantation
KW - Lymphocytic bronchiolitis
UR - http://www.scopus.com/inward/record.url?scp=85028646505&partnerID=8YFLogxK
U2 - 10.1016/j.ccm.2017.07.008
DO - 10.1016/j.ccm.2017.07.008
M3 - Review article
C2 - 29128017
AN - SCOPUS:85028646505
SN - 0272-5231
VL - 38
SP - 667
EP - 675
JO - Clinics in Chest Medicine
JF - Clinics in Chest Medicine
IS - 4
ER -